186114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3551944..3552743 Replicon chromosome
Accession NZ_CP067311
Organism Escherichia coli strain 027_SK3

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag JJB21_RS17170 Protein ID WP_000347273.1
Coordinates 3551944..3552408 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JJB21_RS17175 Protein ID WP_001307405.1
Coordinates 3552408..3552743 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB21_RS17140 (3546945) 3546945..3547379 - 435 WP_097480507.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
JJB21_RS17145 (3547397) 3547397..3548275 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
JJB21_RS17150 (3548265) 3548265..3549044 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
JJB21_RS17155 (3549055) 3549055..3549528 - 474 WP_001723937.1 PTS N-acetylgalactosamine transporter subunit IIB -
JJB21_RS17160 (3549551) 3549551..3550831 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
JJB21_RS17165 (3551080) 3551080..3551889 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JJB21_RS17170 (3551944) 3551944..3552408 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JJB21_RS17175 (3552408) 3552408..3552743 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JJB21_RS17180 (3552892) 3552892..3554463 - 1572 WP_001723936.1 galactarate dehydratase -
JJB21_RS17185 (3554838) 3554838..3556172 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
JJB21_RS17190 (3556188) 3556188..3556958 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3551944..3563617 11673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T186114 WP_000347273.1 NZ_CP067311:c3552408-3551944 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T186114 NZ_CP089220:2083756-2084334 [Mycobacterium intracellulare]
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGAGGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCGTCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAGCGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT186114 WP_001307405.1 NZ_CP067311:c3552743-3552408 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT186114 NZ_CP089220:2083342-2083731 [Mycobacterium intracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References