184332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 605721..606520 Replicon chromosome
Accession NZ_CP066366
Organism Escherichia coli strain AR Bank #0346

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag FNX50_RS02915 Protein ID WP_000347273.1
Coordinates 605721..606185 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag FNX50_RS02920 Protein ID WP_001307405.1
Coordinates 606185..606520 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNX50_RS02885 (600722) 600722..601156 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
FNX50_RS02890 (601174) 601174..602052 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
FNX50_RS02895 (602042) 602042..602821 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
FNX50_RS02900 (602832) 602832..603305 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
FNX50_RS02905 (603328) 603328..604608 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
FNX50_RS02910 (604857) 604857..605666 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
FNX50_RS02915 (605721) 605721..606185 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
FNX50_RS02920 (606185) 606185..606520 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
FNX50_RS02925 (606669) 606669..608240 - 1572 WP_001723936.1 galactarate dehydratase -
FNX50_RS02930 (608615) 608615..609949 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
FNX50_RS02935 (609965) 609965..610735 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 605721..617393 11672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T184332 WP_000347273.1 NZ_CP066366:c606185-605721 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T184332 NZ_CP087618:1938869-1938971 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT184332 WP_001307405.1 NZ_CP066366:c606520-606185 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT184332 NZ_CP087618:c1938978-1938833 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References