Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
Location | 692893..693692 | Replicon | chromosome |
Accession | NZ_CP061758 | ||
Organism | Escherichia coli O68:H12 strain 97.3 |
Toxin (Protein)
Gene name | yhaV | Uniprot ID | V0SSH7 |
Locus tag | IEC98_RS03290 | Protein ID | WP_000347273.1 |
Coordinates | 692893..693357 (-) | Length | 155 a.a. |
Antitoxin (Protein)
Gene name | prlF | Uniprot ID | S1EB98 |
Locus tag | IEC98_RS03295 | Protein ID | WP_001307405.1 |
Coordinates | 693357..693692 (-) | Length | 112 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IEC98_RS03260 | 687893..688327 | - | 435 | WP_000948824.1 | PTS sugar transporter subunit IIA | - |
IEC98_RS03265 | 688345..689224 | - | 880 | Protein_646 | PTS mannose/fructose/sorbose transporter family subunit IID | - |
IEC98_RS03270 | 689214..689993 | - | 780 | WP_000406214.1 | PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC | - |
IEC98_RS03275 | 690004..690477 | - | 474 | WP_001723937.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
IEC98_RS03280 | 690500..691780 | - | 1281 | WP_000681903.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
IEC98_RS03285 | 692029..692838 | + | 810 | WP_000072187.1 | aga operon transcriptional regulator AgaR | - |
IEC98_RS03290 | 692893..693357 | - | 465 | WP_000347273.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
IEC98_RS03295 | 693357..693692 | - | 336 | WP_001307405.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
IEC98_RS03300 | 693841..695412 | - | 1572 | WP_001723936.1 | galactarate dehydratase | - |
IEC98_RS03305 | 695787..697121 | + | 1335 | WP_001723935.1 | galactarate/glucarate/glycerate transporter GarP | - |
IEC98_RS03310 | 697137..697907 | + | 771 | WP_001723934.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 692893..705342 | 12449 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17836.25 Da Isoelectric Point: 9.6924
>T172929 WP_000347273.1 NZ_CP061758:c693357-692893 [Escherichia coli O68:H12]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
Download Length: 465 bp
>T172929 NZ_CP080029:c4833249-4832815 [Streptomyces anulatus]
TTGATCATCGTCGCCGACACCTCGGCCCTCTACGCCGCTTTCGACGCCGCACAGACGGAGCACTCCGAGGCGGCCAGGAT
CCTGGAGAACGAGCGGCTGGCCATCTCCCCCCTGGTCGTCACCGAGCTGGACCACCTGGTCCATCGCGACCTGGGGTTCC
CGGCGGCCATGCAGGTGATGGAGGCATTGAATTCCCGTATGGGCGACGGGCAGTACCGCCTCGCCGAACTCAAGCTCGCG
GACCTGCGTACCGCCCAGGAAGTCCGGCAGAAGTACGAAGGTCTGCGGCTCGACCTGGCCGACGCGGTCGGAGTGGTCCT
CGCCGACCGCTACCGGACGGACCGCATCTTCACCTTGGACCAGCGCGACTTCCGGGCGATGTCACCACTGACCCCCGGAC
TGGACGCCTTCCGGATCCTGCCCGCCGACGGCTGA
TTGATCATCGTCGCCGACACCTCGGCCCTCTACGCCGCTTTCGACGCCGCACAGACGGAGCACTCCGAGGCGGCCAGGAT
CCTGGAGAACGAGCGGCTGGCCATCTCCCCCCTGGTCGTCACCGAGCTGGACCACCTGGTCCATCGCGACCTGGGGTTCC
CGGCGGCCATGCAGGTGATGGAGGCATTGAATTCCCGTATGGGCGACGGGCAGTACCGCCTCGCCGAACTCAAGCTCGCG
GACCTGCGTACCGCCCAGGAAGTCCGGCAGAAGTACGAAGGTCTGCGGCTCGACCTGGCCGACGCGGTCGGAGTGGTCCT
CGCCGACCGCTACCGGACGGACCGCATCTTCACCTTGGACCAGCGCGACTTCCGGGCGATGTCACCACTGACCCCCGGAC
TGGACGCCTTCCGGATCCTGCCCGCCGACGGCTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12358.94 Da Isoelectric Point: 4.8616
>AT172929 WP_001307405.1 NZ_CP061758:c693692-693357 [Escherichia coli O68:H12]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT172929 NZ_CP080029:c4833488-4833246 [Streptomyces anulatus]
ATGATAAAGACGACCGTGTACCTTCCGGAGGAACTGGAAGTGCGACTCGACGCCGAGTCCTCCGCGACCGGCGTCAGCAA
GGCCGAGCTCATCCGGCGGAGCATCGCCCTGCTGCTGGACAGCGCGGAGCGGCCGAAGCGCACTCGGCAGCTGCCCGTCT
TCGACAGCGGACGCTCCCTCACGCCCGACGAGATGGACGACTCGGTGTACGAGCACATCAAAGAGCGGAACGCACGCCGT
TGA
ATGATAAAGACGACCGTGTACCTTCCGGAGGAACTGGAAGTGCGACTCGACGCCGAGTCCTCCGCGACCGGCGTCAGCAA
GGCCGAGCTCATCCGGCGGAGCATCGCCCTGCTGCTGGACAGCGCGGAGCGGCCGAAGCGCACTCGGCAGCTGCCCGTCT
TCGACAGCGGACGCTCCCTCACGCCCGACGAGATGGACGACTCGGTGTACGAGCACATCAAAGAGCGGAACGCACGCCGT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0SSH7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0XVC7 |