Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3717655..3718448 Replicon chromosome
Accession NZ_CP058725
Organism Escherichia coli strain S171-1

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag HZS87_RS18140 Protein ID WP_112921698.1
Coordinates 3717655..3718113 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HZS87_RS18145 Protein ID WP_001307405.1
Coordinates 3718113..3718448 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS87_RS18120 (3713170) 3713170..3714261 - 1092 WP_000816992.1 fimbrial protein -
HZS87_RS18125 (3714272) 3714272..3716788 - 2517 WP_001355538.1 fimbria/pilus outer membrane usher protein -
HZS87_RS18130 (3716817) 3716817..3716909 - 93 Protein_3550 molecular chaperone -
HZS87_RS18135 (3716964) 3716964..3717661 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
HZS87_RS18140 (3717655) 3717655..3718113 - 459 WP_112921698.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HZS87_RS18145 (3718113) 3718113..3718448 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HZS87_RS18150 (3718597) 3718597..3720168 - 1572 WP_112921699.1 galactarate dehydratase -
HZS87_RS18155 (3720543) 3720543..3721877 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
HZS87_RS18160 (3721893) 3721893..3722663 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3717284..3729208 11924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-148)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17545.09 Da        Isoelectric Point: 9.9309

>T167286 WP_112921698.1 NZ_CP058725:c3718113-3717655 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLVMTPTY

Download         Length: 459 bp

>T167286 NZ_CP075109:4564523-4564834 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTAGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT167286 WP_001307405.1 NZ_CP058725:c3718448-3718113 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT167286 NZ_CP075109:4564831-4565277 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References