157925

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 389205..389820 Replicon chromosome
Accession NZ_CP053803
Organism Vibrio cholerae strain L6G

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HPY16_RS14765 Protein ID WP_175248422.1
Coordinates 389205..389492 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HPY16_RS14770 Protein ID WP_001232701.1
Coordinates 389503..389820 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY16_RS14705 384207..384440 + 234 WP_175248420.1 hypothetical protein -
HPY16_RS14710 384484..384921 + 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
HPY16_RS14715 384981..385280 + 300 Protein_389 GNAT family N-acetyltransferase -
HPY16_RS14720 385487..385777 + 291 WP_080536237.1 YkgJ family cysteine cluster protein -
HPY16_RS14725 385802..385921 + 120 WP_020977912.1 DUF3265 domain-containing protein -
HPY16_RS14730 385958..386497 + 540 WP_175231429.1 hydrolase -
HPY16_RS14735 386649..387224 + 576 WP_094129300.1 hypothetical protein -
HPY16_RS14740 387265..387342 + 78 WP_175248608.1 hypothetical protein -
HPY16_RS14745 387492..387723 + 232 Protein_395 DUF645 family protein -
HPY16_RS14750 387910..388197 + 288 WP_000654672.1 hypothetical protein -
HPY16_RS14755 388328..389035 + 708 WP_057562218.1 HAD family hydrolase -
HPY16_RS14760 389042..389164 + 123 WP_175248421.1 acetyltransferase -
HPY16_RS14765 389205..389492 + 288 WP_175248422.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY16_RS14770 389503..389820 + 318 WP_001232701.1 HigA family addiction module antidote protein Antitoxin
HPY16_RS14775 389967..390476 + 510 WP_002053638.1 GNAT family N-acetyltransferase -
HPY16_RS14780 390595..391257 + 663 WP_000084914.1 Vat family streptogramin A O-acetyltransferase -
HPY16_RS14785 391424..392449 + 1026 WP_175231413.1 hypothetical protein -
HPY16_RS14790 392445..392567 + 123 WP_175231869.1 DUF3265 domain-containing protein -
HPY16_RS14795 392603..393019 + 417 WP_175248423.1 ASCH domain-containing protein -
HPY16_RS14800 393196..394083 + 888 WP_175248424.1 FRG domain-containing protein -
HPY16_RS14805 394108..394201 + 94 Protein_407 DUF3265 domain-containing protein -
HPY16_RS14810 394229..394735 + 507 WP_114742457.1 SLATT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCARB-7 - 309435..510278 200843
- inside Integron - - 310548..509407 198859
flank IS/Tn - - 384484..384921 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11322.92 Da        Isoelectric Point: 6.7187

>T157925 WP_175248422.1 NZ_CP053803:389205-389492 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGSLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T157925 NZ_CP069517:c1154869-1153547 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGAGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAATGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT157925 WP_001232701.1 NZ_CP053803:389503-389820 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT157925 NZ_CP069517:c1155135-1154869 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAATGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTAACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCAAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References