Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 18834..19467 | Replicon | chromosome |
| Accession | NZ_CP046845 | ||
| Organism | Vibrio cholerae C6706 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | GPY04_RS14145 | Protein ID | WP_000843587.1 |
| Coordinates | 19135..19467 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GPY04_RS14140 | Protein ID | WP_000071008.1 |
| Coordinates | 18834..19148 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY04_RS14090 | 13888..14175 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY04_RS14095 | 14165..14416 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY04_RS14100 | 14630..15043 | - | 414 | WP_000049417.1 | VOC family protein | - |
| GPY04_RS14105 | 15118..15261 | - | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14110 | 15231..15632 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| GPY04_RS14115 | 15632..16324 | - | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS14120 | 16461..16767 | - | 307 | Protein_32 | CatB-related O-acetyltransferase | - |
| GPY04_RS14125 | 16835..17815 | + | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
| GPY04_RS14130 | 17940..18095 | - | 156 | WP_000751734.1 | hypothetical protein | - |
| GPY04_RS14135 | 18263..18697 | - | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS14140 | 18834..19148 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| GPY04_RS14145 | 19135..19467 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY04_RS14155 | 19808..20035 | - | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
| GPY04_RS14160 | 19984..20097 | - | 114 | WP_001889158.1 | hypothetical protein | - |
| GPY04_RS14170 | 20263..20544 | - | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
| GPY04_RS19350 | 20493..20607 | - | 115 | Protein_41 | acetyltransferase | - |
| GPY04_RS14175 | 20664..21041 | - | 378 | WP_000411109.1 | hypothetical protein | - |
| GPY04_RS14180 | 21212..21454 | - | 243 | WP_000107461.1 | hypothetical protein | - |
| GPY04_RS14185 | 21656..22042 | - | 387 | WP_000703163.1 | VOC family protein | - |
| GPY04_RS14190 | 22251..22422 | - | 172 | Protein_45 | DUF645 family protein | - |
| GPY04_RS14195 | 22740..23009 | - | 270 | WP_001198131.1 | hypothetical protein | - |
| GPY04_RS14200 | 23369..23542 | - | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
| GPY04_RS19355 | 23823..24026 | - | 204 | WP_001911745.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | catB9 | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 113..1070288 | 1070175 | |
| flank | IS/Tn | - | - | 16835..17815 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T145082 WP_000843587.1 NZ_CP046845:c19467-19135 [Vibrio cholerae C6706]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T145082 NZ_CP062254:876056-876469 [Pectobacterium parmentieri]
GTGGCCCAGTGGCAATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGTCTATTAGTGTT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTGTGGCTGTGTTTGGTCACAATGGTGATGTTTGGTTTCA
TCCGTAGCCAAAGGAATATCAAATCGCGGCAAGGGTGCATCACGCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAGTGGCGGATTGTCAAACGACCGTGGTTGCTGAAAAATGGTGTGTTATTGGCATTGCAATCGGCTAATGGGAAAGACAA
GCAACAACTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCATCTGCGCCAGCTTCTTTTGCAGCAAAAAC
ACTGGGCGAGATGA
GTGGCCCAGTGGCAATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGTCTATTAGTGTT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTGTGGCTGTGTTTGGTCACAATGGTGATGTTTGGTTTCA
TCCGTAGCCAAAGGAATATCAAATCGCGGCAAGGGTGCATCACGCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAGTGGCGGATTGTCAAACGACCGTGGTTGCTGAAAAATGGTGTGTTATTGGCATTGCAATCGGCTAATGGGAAAGACAA
GCAACAACTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCATCTGCGCCAGCTTCTTTTGCAGCAAAAAC
ACTGGGCGAGATGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT145082 WP_000071008.1 NZ_CP046845:c19148-18834 [Vibrio cholerae C6706]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT145082 NZ_CP062254:875809-876075 [Pectobacterium parmentieri]
ATGGAAATCGATAACAAATCACGTATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTGGATATCGCCATCATGCCGTT
TTTTGAGCATGACTATGACACATTAAACGATATAGATAAGCGCACGTTTGTACGCCTGCTACAAAGCGACGATCCCGATT
TATTCAACTGGCTAATGAACCACGGTGAGCCAGAAGACGGAGAGCTAAAACGCATGATTTCCCTTATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA
ATGGAAATCGATAACAAATCACGTATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTGGATATCGCCATCATGCCGTT
TTTTGAGCATGACTATGACACATTAAACGATATAGATAAGCGCACGTTTGTACGCCTGCTACAAAGCGACGATCCCGATT
TATTCAACTGGCTAATGAACCACGGTGAGCCAGAAGACGGAGAGCTAAAACGCATGATTTCCCTTATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|