144874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 592660..593293 Replicon chromosome
Accession NZ_CP046743
Organism Vibrio cholerae strain 3569-08

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GPW72_RS02755 Protein ID WP_000843587.1
Coordinates 592961..593293 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GPW72_RS02750 Protein ID WP_000071008.1
Coordinates 592660..592974 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW72_RS02700 587714..588001 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPW72_RS02705 587991..588242 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPW72_RS02710 588456..588869 - 414 WP_000049417.1 VOC family protein -
GPW72_RS02715 588944..589087 - 144 WP_071908341.1 DUF3265 domain-containing protein -
GPW72_RS02720 589057..589458 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GPW72_RS02725 589458..590150 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
GPW72_RS02730 590287..590593 - 307 Protein_526 CatB-related O-acetyltransferase -
GPW72_RS02735 590661..591641 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GPW72_RS02740 591766..591921 - 156 WP_000751734.1 hypothetical protein -
GPW72_RS02745 592089..592523 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
GPW72_RS02750 592660..592974 - 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
GPW72_RS02755 592961..593293 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW72_RS02765 593634..593861 - 228 WP_001894457.1 DUF1289 domain-containing protein -
GPW72_RS02770 593810..593923 - 114 WP_001889158.1 hypothetical protein -
GPW72_RS02780 594089..594370 - 282 WP_001894453.1 DUF1289 domain-containing protein -
GPW72_RS19175 594319..594433 - 115 Protein_535 acetyltransferase -
GPW72_RS02785 594490..594867 - 378 WP_000411109.1 hypothetical protein -
GPW72_RS02790 595038..595280 - 243 WP_000107461.1 hypothetical protein -
GPW72_RS02795 595482..595868 - 387 WP_000703163.1 VOC family protein -
GPW72_RS02800 596077..596248 - 172 Protein_539 DUF645 family protein -
GPW72_RS02805 596566..596835 - 270 WP_001198131.1 hypothetical protein -
GPW72_RS02810 597195..597368 - 174 WP_001882305.1 DUF3709 domain-containing protein -
GPW72_RS19180 597649..597852 - 204 WP_001911745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 575627..724145 148518
- inside Integron - - 575627..717201 141574
flank IS/Tn - - 590661..591641 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T144874 WP_000843587.1 NZ_CP046743:c593293-592961 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T144874 NZ_CP062244:2759277-2760350 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT144874 WP_000071008.1 NZ_CP046743:c592974-592660 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT144874 NZ_CP062244:2760343-2760714 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References