Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 838658..839291 | Replicon | chromosome |
| Accession | NZ_CP045718 | ||
| Organism | Vibrio cholerae O395 substr. TCP2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | GG844_RS03835 | Protein ID | WP_000843587.1 |
| Coordinates | 838959..839291 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GG844_RS03830 | Protein ID | WP_000071008.1 |
| Coordinates | 838658..838972 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GG844_RS03780 | 833712..833999 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GG844_RS03785 | 833989..834240 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GG844_RS03790 | 834454..834867 | - | 414 | WP_000049417.1 | VOC family protein | - |
| GG844_RS03795 | 834942..835085 | - | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| GG844_RS03800 | 835055..835456 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| GG844_RS03805 | 835456..836148 | - | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
| GG844_RS03810 | 836319..836591 | - | 273 | Protein_739 | CatB-related O-acetyltransferase | - |
| GG844_RS03815 | 836659..837639 | + | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
| GG844_RS03820 | 837764..837919 | - | 156 | WP_000751734.1 | hypothetical protein | - |
| GG844_RS03825 | 838087..838521 | - | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| GG844_RS03830 | 838658..838972 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| GG844_RS03835 | 838959..839291 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GG844_RS03845 | 839632..839859 | - | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
| GG844_RS19655 | 839808..839922 | - | 115 | Protein_746 | acetyltransferase | - |
| GG844_RS03850 | 840039..840210 | - | 172 | Protein_747 | DUF645 family protein | - |
| GG844_RS03855 | 840528..840797 | - | 270 | WP_001198131.1 | hypothetical protein | - |
| GG844_RS03860 | 841157..841330 | - | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
| GG844_RS19660 | 841611..841814 | - | 204 | WP_001911745.1 | hypothetical protein | - |
| GG844_RS03875 | 842101..842652 | - | 552 | WP_000821930.1 | hypothetical protein | - |
| GG844_RS03880 | 842808..843665 | - | 858 | WP_001279526.1 | DUF2806 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 833007..914523 | 81516 | |
| flank | IS/Tn | - | - | 836659..837639 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T142375 WP_000843587.1 NZ_CP045718:c839291-838959 [Vibrio cholerae O395]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T142375 NZ_CP060672:c4517270-4516995 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT142375 WP_000071008.1 NZ_CP045718:c838972-838658 [Vibrio cholerae O395]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT142375 NZ_CP060672:c4517533-4517273 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|