MGE detailed information
MGE type: Non-Mobilizable plasmid MGE length: 191041 bp
Accession: NZ_CP063931 Location: 1..191041 Organism: Klebsiella pneumoniae strain M186-2 Replicon: plasmid pM186-2
Accession: NZ_CP063931 Location: 1..191041 Organism: Klebsiella pneumoniae strain M186-2 Replicon: plasmid pM186-2
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ISA67_RS25270 () | 772..1668 | - | 897 | WP_023345580.1 | HTH-type transcriptional regulator DmlR | VF |
| ISA67_RS25275 () | 1768..2949 | + | 1182 | WP_023345579.1 | MFS transporter | - |
| ISA67_RS25280 () | 3068..3676 | - | 609 | WP_023345578.1 | short chain dehydrogenase | - |
| ISA67_RS25285 () | 3774..4676 | + | 903 | WP_048265000.1 | LysR family transcriptional regulator | - |
| ISA67_RS25290 () | 4988..5685 | - | 698 | Protein_5 | IS1 family transposase IS1G | Transposase |
| ISA67_RS25295 () | 5736..6044 | - | 309 | WP_064167953.1 | hypothetical protein | - |
| ISA67_RS25300 () | 6128..6655 | - | 528 | WP_072198182.1 | GNAT family N-acetyltransferase | Toxin Detail |
| ISA67_RS25305 () | 6663..6932 | - | 270 | WP_048264996.1 | DUF1778 domain-containing protein | Antitoxin Detail |
| ISA67_RS25310 () | 7860..9035 | + | 1176 | WP_077258344.1 | SAVED domain-containing protein | - |
| ISA67_RS25315 () | 9032..10279 | + | 1248 | WP_048264960.1 | nucleotidyltransferase | - |
| ISA67_RS25320 () | 10281..12044 | + | 1764 | WP_048265023.1 | ThiF family adenylyltransferase | - |
| ISA67_RS25325 () | 12041..12538 | + | 498 | WP_048264961.1 | Mov34/MPN/PAD-1 family protein | - |
| ISA67_RS25330 () | 12552..13094 | - | 543 | WP_000994210.1 | 3'-5' exonuclease | - |
| ISA67_RS25335 () | 13303..14297 | - | 995 | Protein_14 | IS110 family transposase IS1663 | Transposase |
| ISA67_RS25340 () | 16483..18015 | - | 1533 | WP_194444815.1 | IS3 family transposase ISKpn38 | Transposase |
| ISA67_RS25345 () | 18109..19188 | - | 1080 | WP_023345572.1 | alanine racemase | - |
| ISA67_RS25350 () | 19328..20113 | - | 786 | WP_048264964.1 | ABC transporter substrate-binding protein | - |
| ISA67_RS25355 () | 20356..21129 | - | 774 | WP_023345570.1 | Histidine transport ATP-binding protein HisP | VF |
| ISA67_RS25360 () | 21139..21855 | - | 717 | WP_023345569.1 | ABC transporter permease | - |
| ISA67_RS25365 () | 21852..22538 | - | 687 | WP_064167955.1 | histidine ABC transporter permease HisQ | - |
| ISA67_RS25370 () | 22607..23593 | - | 987 | WP_048264966.1 | succinylglutamate desuccinylase | - |
| ISA67_RS25375 () | 23593..25089 | - | 1497 | WP_087771554.1 | succinylglutamate-semialdehyde dehydrogenase | - |
| ISA67_RS25380 () | 25093..26130 | - | 1038 | WP_048264967.1 | arginine N-succinyltransferase | - |
| ISA67_RS25385 () | 26127..27365 | - | 1239 | WP_048291908.1 | bifunctional succinylornithine transaminase/acetylornithine transaminase | - |
| ISA67_RS25390 () | 27741..28658 | - | 918 | WP_048264969.1 | amidinotransferase | - |
| ISA67_RS25395 () | 28681..29694 | - | 1014 | WP_053065131.1 | ornithine cyclodeaminase | - |
| ISA67_RS25400 () | 29819..30241 | + | 423 | WP_048264970.1 | Lrp/AsnC family transcriptional regulator | - |
| ISA67_RS25405 () | 30299..30496 | - | 198 | Protein_28 | IS630 family transposase | - |
| ISA67_RS25410 () | 30543..33461 | - | 2919 | Protein_29 | Tn3 family transposase ISEc63 | Transposase |
| ISA67_RS25415 () | 33606..35627 | - | 2022 | WP_048264972.1 | Pesticin receptor | VF |
| ISA67_RS25420 () | 35758..37335 | - | 1578 | WP_048264973.1 | 2,3-dihydroxybenzoate-AMP ligase | VF |
| ISA67_RS25425 () | 37339..38142 | - | 804 | WP_000194284.1 | Surfactin synthase thioesterase subunit | VF |
| ISA67_RS25430 () | 38139..39239 | - | 1101 | WP_000982866.1 | hypothetical protein | VF |
| ISA67_RS25435 () | 39236..48727 | - | 9492 | WP_075647613.1 | Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsE | VF |
| ISA67_RS25440 () | 48815..54944 | - | 6130 | Protein_35 | Anguibactin system regulator | VF |
| ISA67_RS25445 () | 55135..56094 | - | 960 | WP_048264977.1 | Regulatory protein PchR | VF |
| ISA67_RS25450 () | 56351..58063 | + | 1713 | WP_048264980.1 | Iron import ATP-binding/permease protein IrtA | VF |
| ISA67_RS25455 () | 58050..59852 | + | 1803 | WP_025368102.1 | Putative multidrug export ATP-binding/permease protein | VF |
| ISA67_RS25460 () | 59845..61125 | + | 1281 | WP_048264981.1 | Protein AmpG | VF |
| ISA67_RS25465 () | 61153..62457 | + | 1305 | WP_065809517.1 | Salicylate synthase | VF |
| ISA67_RS25470 () | 62680..62888 | + | 209 | Protein_41 | mucoid phenotype A regulator RmpA | - |
| ISA67_RS25475 () | 63189..63410 | - | 222 | WP_131023892.1 | hypothetical protein | - |
| ISA67_RS25480 () | 64174..64356 | + | 183 | WP_126033889.1 | hypothetical protein | - |
| ISA67_RS25485 () | 64431..65120 | - | 690 | WP_048264983.1 | EAL domain-containing protein | - |
| ISA67_RS25490 () | 65693..66390 | - | 698 | Protein_45 | IS1 family transposase IS1G | Transposase |
| ISA67_RS25495 () | 66463..67341 | - | 879 | WP_032738453.1 | EamA family transporter | - |
| ISA67_RS25500 () | 67352..68701 | - | 1350 | WP_077268819.1 | aspartate aminotransferase family protein | - |
| ISA67_RS25505 () | 68704..69762 | - | 1059 | WP_053065465.1 | phosphotransferase | - |
| ISA67_RS25510 () | 70026..70772 | + | 747 | WP_023345553.1 | GntR family transcriptional regulator | - |
| ISA67_RS25515 () | 70802..71554 | - | 753 | WP_023345554.1 | Glutamine transport ATP-binding protein GlnQ | VF |
| ISA67_RS25520 () | 71571..72254 | - | 684 | WP_023345555.1 | ABC transporter permease | - |
| ISA67_RS25525 () | 72257..72967 | - | 711 | WP_023345556.1 | ABC transporter permease subunit | - |
| ISA67_RS25530 () | 72995..73768 | - | 774 | WP_048265027.1 | Lysine/arginine/ornithine-binding periplasmic protein | VF |
| ISA67_RS25535 () | 74196..75434 | - | 1239 | WP_065809528.1 | IS110 family transposase ISCps4 | Transposase |
| ISA67_RS25540 () | 76058..77053 | + | 996 | WP_105002553.1 | IS110 family transposase IS1663 | Transposase |
| ISA67_RS25545 () | 77244..78086 | + | 843 | WP_053065109.1 | hypothetical protein | - |
| ISA67_RS25555 () | 79642..79890 | + | 249 | Protein_58 | transposase | - |
| ISA67_RS25560 () | 80953..81650 | - | 698 | Protein_59 | IS1 family transposase IS1G | Transposase |
| ISA67_RS25565 () | 82133..82603 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin Detail |
| ISA67_RS25570 () | 82600..83043 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin Detail |
| ISA67_RS25575 () | 83144..83647 | - | 504 | Protein_62 | DUF4113 domain-containing protein | - |
| ISA67_RS25580 () | 83745..83966 | - | 222 | WP_004213643.1 | DUF2188 domain-containing protein | - |
| ISA67_RS25585 () | 84111..84266 | - | 156 | WP_004213642.1 | hypothetical protein | - |
| ISA67_RS25590 () | 84341..86467 | - | 2127 | WP_004213640.1 | TonB-dependent receptor family protein | - |
| ISA67_RS25595 () | 86554..87507 | - | 954 | Protein_66 | fec operon regulator FecR | - |
| ISA67_RS25600 () | 87504..88025 | - | 522 | WP_004213635.1 | putative RNA polymerase sigma factor FecI | VF |
| ISA67_RS25605 () | 88250..88456 | + | 207 | WP_011154590.1 | IS3 family transposase ISKpn37 | Transposase |
| ISA67_RS25610 () | 88564..88758 | + | 195 | Protein_69 | IS66 family transposase ISEc23 | Transposase |
| ISA67_RS25615 () | 88913..90145 | + | 1233 | WP_004213628.1 | phosphoadenosine phosphosulfate reductase | - |
| ISA67_RS25620 () | 90130..90774 | + | 645 | WP_004213626.1 | ParB N-terminal domain-containing protein | - |
| ISA67_RS25625 () | 90881..91108 | + | 228 | WP_074160420.1 | IS110 family transposase ISCps4 | Transposase |
| ISA67_RS25630 () | 91124..92239 | + | 1116 | WP_004213623.1 | Elloramycin glycosyltransferase ElmGT | VF |
| ISA67_RS25635 () | 92382..96026 | + | 3645 | WP_023302798.1 | Multidrug efflux ATP-binding/permease protein | VF |
| ISA67_RS25640 () | 96131..97360 | + | 1230 | WP_004902400.1 | Enterochelin esterase | VF |
| ISA67_RS25645 () | 97820..99994 | + | 2175 | WP_004213617.1 | Ferric enterobactin receptor | VF |
| ISA67_RS25650 () | 100056..100277 | + | 222 | WP_004213615.1 | hypothetical protein | - |
| ISA67_RS25655 () | 100420..101322 | - | 903 | WP_004213613.1 | DMT family transporter | - |
| ISA67_RS25660 () | 101395..101946 | - | 552 | WP_004213611.1 | response regulator transcription factor | - |
| ISA67_RS25665 () | 102124..102307 | - | 184 | Protein_80 | small membrane protein | - |
| ISA67_RS25670 () | 102327..102959 | - | 633 | WP_004213609.1 | hypothetical protein | VF |
| ISA67_RS25675 () | 103503..104156 | + | 654 | WP_023302796.1 | class I SAM-dependent methyltransferase | - |
| ISA67_RS25680 () | 104226..104492 | - | 267 | Protein_83 | IS3 family transposase | - |
| ISA67_RS25685 () | 104503..105191 | - | 689 | Protein_84 | IS1 family transposase | - |
| ISA67_RS25690 () | 105340..105663 | - | 324 | WP_004902375.1 | hypothetical protein | - |
| ISA67_RS25695 () | 106035..107003 | - | 969 | WP_004225014.1 | IS5 family transposase IS903B | Transposase |
| ISA67_RS25700 () | 107037..107516 | + | 480 | Protein_87 | VWA domain-containing protein | - |
| ISA67_RS25705 () | 107541..108182 | + | 642 | WP_004026586.1 | TerD family protein | - |
| ISA67_RS25710 () | 108183..108821 | + | 639 | WP_004026585.1 | VWA domain-containing protein | - |
| ISA67_RS25715 () | 108914..109954 | + | 1041 | WP_004026583.1 | VWA domain-containing protein | - |
| ISA67_RS25720 () | 109954..111687 | + | 1734 | WP_064153636.1 | protein phosphatase 2C domain-containing protein | - |
| ISA67_RS25725 () | 111715..113214 | + | 1500 | WP_048333030.1 | kinase | - |
| ISA67_RS25730 () | 113346..113993 | - | 648 | WP_014386537.1 | EcsC family protein | - |
| ISA67_RS25735 () | 114020..114775 | - | 756 | WP_004902235.1 | DUF2971 domain-containing protein | - |
| ISA67_RS25740 () | 114876..115268 | - | 393 | WP_032442757.1 | hypothetical protein | - |
| ISA67_RS25745 () | 115373..115912 | - | 540 | WP_004902239.1 | hypothetical protein | - |
| ISA67_RS25750 () | 116947..117429 | - | 483 | WP_048333033.1 | GNAT family N-acetyltransferase | Toxin Detail |
| ISA67_RS25755 () | 117420..117698 | - | 279 | WP_004902250.1 | DUF1778 domain-containing protein | Antitoxin Detail |
| ISA67_RS25760 () | 117820..118032 | - | 213 | WP_194444813.1 | hypothetical protein | - |
| ISA67_RS25765 () | 118140..118481 | - | 342 | WP_032437747.1 | hypothetical protein | - |
| ISA67_RS25770 () | 119387..119701 | + | 315 | WP_040210113.1 | hypothetical protein | - |
| ISA67_RS25775 () | 119944..120402 | - | 459 | WP_173675456.1 | hypothetical protein | - |
| ISA67_RS25780 () | 121654..122538 | + | 885 | WP_004186900.1 | hypothetical protein | - |
| ISA67_RS25785 () | 122699..123655 | + | 957 | WP_180297167.1 | hypothetical protein | - |
| ISA67_RS25790 () | 123874..124941 | - | 1068 | WP_016946353.1 | hypothetical protein | - |
| ISA67_RS25795 () | 125027..125281 | - | 255 | WP_065809477.1 | hypothetical protein | - |
| ISA67_RS25800 () | 125458..126594 | + | 1137 | WP_014386529.1 | tyrosine-type recombinase/integrase | - |
| ISA67_RS25805 () | 126660..126977 | - | 318 | WP_004026552.1 | hypothetical protein | - |
| ISA67_RS25810 () | 127129..127452 | - | 324 | WP_004186935.1 | hypothetical protein | - |
| ISA67_RS25815 () | 127449..128207 | - | 759 | WP_004181760.1 | hypothetical protein | - |
| ISA67_RS25820 () | 128204..129163 | - | 960 | WP_004026549.1 | DNA replication protein | - |
| ISA67_RS25825 () | 129206..129613 | - | 408 | WP_024198103.1 | hypothetical protein | - |
| ISA67_RS25830 () | 129623..130087 | - | 465 | WP_004181762.1 | hypothetical protein | - |
| ISA67_RS25835 () | 130135..130377 | - | 243 | WP_004026547.1 | hypothetical protein | - |
| ISA67_RS25840 () | 130364..130969 | - | 606 | WP_048291865.1 | hypothetical protein | - |
| ISA67_RS25845 () | 131002..131384 | + | 383 | Protein_116 | IS3 family transposase ISEam1 | Transposase |
| ISA67_RS25850 () | 131534..131650 | + | 117 | Protein_117 | IS3 family transposase ISYpe1 | Transposase |
| ISA67_RS25855 () | 131875..132891 | - | 1017 | Protein_118 | IS110 family transposase ISSaen1 | Transposase |
| ISA67_RS25860 () | 132958..133940 | + | 983 | Protein_119 | IS3 family transposase ISYps8 | Transposase |
| ISA67_RS25865 () | 134151..134687 | + | 537 | WP_032414401.1 | hypothetical protein | - |
| ISA67_RS25870 () | 134825..135098 | - | 274 | Protein_121 | IS3 family transposase | - |
| ISA67_RS25875 () | 135446..136186 | + | 741 | Protein_122 | site-specific integrase | - |
| ISA67_RS25880 () | 137008..138018 | - | 1011 | WP_048291867.1 | RepB family plasmid replication initiator protein | - |
| ISA67_RS25885 () | 138748..139914 | + | 1167 | WP_004211841.1 | Sporulation initiation inhibitor protein Soj | VF |
| ISA67_RS25890 () | 139914..140885 | + | 972 | WP_004117790.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| ISA67_RS25895 () | 142251..142479 | - | 229 | Protein_126 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| ISA67_RS25900 () | 142558..142782 | - | 225 | WP_127807699.1 | DUF4113 domain-containing protein | - |
| ISA67_RS25905 () | 142712..143086 | - | 375 | WP_173675457.1 | hypothetical protein | - |
| ISA67_RS25910 () | 143141..144186 | - | 1046 | Protein_129 | IS3 family transposase ISYps8 | Transposase |
| ISA67_RS25915 () | 144581..144922 | - | 342 | WP_048291869.1 | hypothetical protein | - |
| ISA67_RS25920 () | 144922..145659 | - | 738 | Protein_131 | DUF1311 domain-containing protein | - |
| ISA67_RS25925 () | 146083..146304 | + | 222 | WP_072060588.1 | DUF2188 domain-containing protein | - |
| ISA67_RS25930 () | 146405..146911 | + | 507 | Protein_133 | DUF4113 domain-containing protein | - |
| ISA67_RS25935 () | 147012..147455 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin Detail |
| ISA67_RS25940 () | 147452..147922 | + | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin Detail |
| ISA67_RS25945 () | 148033..148293 | - | 261 | WP_048291871.1 | hypothetical protein | - |
| ISA67_RS25950 () | 148989..149498 | + | 510 | WP_004901294.1 | IS3 family transposase ISKpn8 | Transposase |
| ISA67_RS25955 () | 149453..150268 | + | 816 | WP_077268817.1 | IS3 family transposase ISKpn8 | Transposase |
| ISA67_RS25965 () | 151437..151583 | + | 147 | WP_159193595.1 | IS3 family transposase | - |
| ISA67_RS25970 () | 151784..152212 | + | 429 | WP_004901287.1 | GFA family protein | - |
| ISA67_RS25975 () | 152345..152611 | + | 267 | WP_003026799.1 | DUF1778 domain-containing protein | Antitoxin Detail |
| ISA67_RS25980 () | 152599..153084 | + | 486 | WP_021312536.1 | GNAT family N-acetyltransferase | Toxin Detail |
| ISA67_RS25985 () | 153427..153588 | + | 162 | WP_004118124.1 | type I toxin-antitoxin system Hok family toxin | - |
| ISA67_RS25990 () | 154193..155167 | + | 975 | WP_048291873.1 | hypothetical protein | - |
| ISA67_RS25995 () | 155364..155741 | - | 378 | WP_032719541.1 | hypothetical protein | - |
| ISA67_RS26000 () | 155975..156271 | + | 297 | WP_048291874.1 | hypothetical protein | - |
| ISA67_RS26005 () | 156340..157407 | + | 1068 | WP_048291875.1 | hypothetical protein | - |
| ISA67_RS26010 () | 157503..157940 | + | 438 | WP_126034224.1 | hypothetical protein | - |
| ISA67_RS26015 () | 158023..158370 | + | 348 | WP_065809522.1 | hypothetical protein | - |
| ISA67_RS26020 () | 158449..158681 | + | 233 | Protein_151 | hypothetical protein | - |
| ISA67_RS26025 () | 159212..159568 | + | 357 | WP_004181906.1 | hypothetical protein | - |
| ISA67_RS26030 () | 159622..160041 | - | 420 | Protein_153 | NERD domain-containing protein | - |
| ISA67_RS26035 () | 160037..162979 | - | 2943 | WP_065809521.1 | hypothetical protein | Relaxase |
| ISA67_RS26040 () | 162993..163781 | - | 789 | WP_048291879.1 | hypothetical protein | - |
| ISA67_RS26045 () | 163781..164245 | - | 465 | WP_065809520.1 | hypothetical protein | - |
| ISA67_RS26050 () | 164841..165595 | + | 755 | Protein_157 | hypothetical protein | - |
| ISA67_RS26055 () | 165788..166310 | + | 523 | Protein_158 | hypothetical protein | - |
| ISA67_RS26060 () | 166327..166869 | + | 543 | WP_072060590.1 | hypothetical protein | - |
| ISA67_RS26065 () | 167235..168272 | + | 1038 | WP_048291881.1 | conjugal transfer protein TraF | - |
| ISA67_RS26070 () | 168262..169671 | + | 1410 | WP_004026310.1 | conjugal transfer protein TraH | - |
| ISA67_RS26075 () | 169673..171907 | + | 2235 | Protein_162 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
| ISA67_RS26085 () | 173104..173451 | + | 348 | WP_165451970.1 | DUF1173 family protein | - |
| ISA67_RS26090 () | 173600..173905 | + | 306 | WP_126034233.1 | hypothetical protein | - |
| ISA67_RS26095 () | 174227..175012 | - | 786 | WP_048291886.1 | site-specific integrase | - |
| ISA67_RS26100 () | 175211..176199 | - | 989 | Protein_167 | hypothetical protein | - |
| ISA67_RS26105 () | 176386..176691 | - | 306 | WP_004197633.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| ISA67_RS26110 () | 176693..176911 | - | 219 | WP_015632547.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| ISA67_RS26115 () | 177190..178563 | + | 1374 | WP_048265005.1 | hypothetical protein | - |
| ISA67_RS26120 () | 178905..179333 | - | 429 | WP_088476845.1 | nuclear transport factor 2 family protein | - |
| ISA67_RS26125 () | 179446..180291 | - | 846 | WP_023345593.1 | SDR family oxidoreductase | - |
| ISA67_RS26130 () | 180394..180789 | + | 396 | WP_023345592.1 | helix-turn-helix transcriptional regulator | - |
| ISA67_RS26135 () | 180901..181485 | + | 585 | WP_023345591.1 | TetR/AcrR family transcriptional regulator | - |
| ISA67_RS26140 () | 181553..182395 | + | 843 | WP_048291887.1 | nitroreductase family protein | - |
| ISA67_RS26145 () | 182814..183044 | + | 231 | WP_023345588.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin Detail |
| ISA67_RS26150 () | 183041..183457 | + | 417 | WP_023345587.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| ISA67_RS26155 () | 183549..184952 | - | 1404 | WP_023345586.1 | glycoside hydrolase family 1 protein | - |
| ISA67_RS26160 () | 184962..186836 | - | 1875 | WP_048291888.1 | beta-glucoside-specific PTS transporter subunit IIABC | - |
| ISA67_RS26165 () | 187225..187860 | - | 636 | WP_023345584.1 | DUF1349 domain-containing protein | - |
| ISA67_RS26170 () | 187899..189104 | - | 1206 | WP_077258347.1 | MFS transporter | - |
| ISA67_RS26175 () | 189189..189959 | + | 771 | WP_023345582.1 | HTH-type transcriptional regulator NimR | VF |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|