Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 182814..183457 Replicon plasmid pM186-2
Accession NZ_CP063931
Organism Klebsiella pneumoniae strain M186-2

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag ISA67_RS26150 Protein ID WP_023345587.1
Coordinates 183041..183457 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag ISA67_RS26145 Protein ID WP_023345588.1
Coordinates 182814..183044 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA67_RS26120 178905..179333 - 429 WP_088476845.1 nuclear transport factor 2 family protein -
ISA67_RS26125 179446..180291 - 846 WP_023345593.1 SDR family oxidoreductase -
ISA67_RS26130 180394..180789 + 396 WP_023345592.1 helix-turn-helix transcriptional regulator -
ISA67_RS26135 180901..181485 + 585 WP_023345591.1 TetR/AcrR family transcriptional regulator -
ISA67_RS26140 181553..182395 + 843 WP_048291887.1 nitroreductase family protein -
ISA67_RS26145 182814..183044 + 231 WP_023345588.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ISA67_RS26150 183041..183457 + 417 WP_023345587.1 type II toxin-antitoxin system VapC family toxin Toxin
ISA67_RS26155 183549..184952 - 1404 WP_023345586.1 glycoside hydrolase family 1 protein -
ISA67_RS26160 184962..186836 - 1875 WP_048291888.1 beta-glucoside-specific PTS transporter subunit IIABC -
ISA67_RS26165 187225..187860 - 636 WP_023345584.1 DUF1349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS / iroB / iroC / iroD / iroN / rmpA 1..191041 191041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15082.55 Da        Isoelectric Point: 7.8644

>T179660 WP_023345587.1 NZ_CP063931:183041-183457 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLMLEDWVN

Download         Length: 417 bp

>T179660 NZ_CP084868:c3637913-3637811 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT179660 WP_023345588.1 NZ_CP063931:182814-183044 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFAP

Download         Length: 231 bp

>AT179660 NZ_CP084868:3637804-3637949 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References