MGE detailed information
MGE type: Conjugative plasmid MGE length: 133735 bp
Accession: NZ_CP015077 Location: 1..133735 Organism: Escherichia coli strain Ecol_448 Replicon: plasmid pEC448_1
Accession: NZ_CP015077 Location: 1..133735 Organism: Escherichia coli strain Ecol_448 Replicon: plasmid pEC448_1
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A4R37_RS24895 () | 1..363 | - | 363 | WP_000338606.1 | type IV conjugative transfer system pilin TraA | - |
| A4R37_RS24900 () | 397..624 | - | 228 | WP_001254388.1 | conjugal transfer relaxosome protein TraY | - |
| A4R37_RS24905 () | 712..1389 | - | 678 | WP_001348626.1 | PAS domain-containing protein | - |
| A4R37_RS24910 () | 1523..1906 | - | 384 | WP_001151566.1 | relaxosome protein TraM | - |
| A4R37_RS24915 () | 2237..2839 | + | 603 | WP_000243712.1 | hypothetical protein | VF |
| A4R37_RS24920 () | 3136..3957 | - | 822 | WP_001234469.1 | DUF945 domain-containing protein | - |
| A4R37_RS24925 () | 4075..4362 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| A4R37_RS29800 () | 4387..4593 | - | 207 | WP_000275859.1 | hypothetical protein | - |
| A4R37_RS29805 () | 4506..4841 | - | 336 | WP_013023876.1 | hypothetical protein | - |
| A4R37_RS24940 () | 5284..5442 | - | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| - () | 5486..5613 | - | 128 | NuclAT_0 | - | Antitoxin Detail |
| - () | 5486..5613 | - | 128 | NuclAT_0 | - | Antitoxin Detail |
| - () | 5486..5613 | - | 128 | NuclAT_0 | - | Antitoxin Detail |
| - () | 5486..5613 | - | 128 | NuclAT_0 | - | Antitoxin Detail |
| - () | 7055..7157 | - | 103 | NuclAT_1 | - | - |
| - () | 7055..7157 | - | 103 | NuclAT_1 | - | - |
| - () | 7055..7157 | - | 103 | NuclAT_1 | - | - |
| - () | 7055..7157 | - | 103 | NuclAT_1 | - | - |
| A4R37_RS24960 () | 7169..7888 | - | 720 | WP_001276232.1 | plasmid SOS inhibition protein A | - |
| A4R37_RS24965 () | 7885..8319 | - | 435 | WP_000845940.1 | conjugation system SOS inhibitor PsiB | - |
| A4R37_RS24970 () | 8374..10332 | - | 1959 | WP_000117179.1 | ParB/RepB/Spo0J family partition protein | - |
| A4R37_RS24975 () | 10398..10631 | - | 234 | WP_000005990.1 | DUF905 family protein | - |
| A4R37_RS24980 () | 10694..11233 | - | 540 | WP_000290841.1 | single-stranded DNA-binding protein | - |
| A4R37_RS29810 () | 11378..11713 | - | 336 | WP_013023883.1 | hypothetical protein | - |
| A4R37_RS28755 () | 11876..12088 | - | 213 | WP_063131930.1 | hypothetical protein | - |
| A4R37_RS24995 () | 12114..12677 | - | 564 | WP_001348621.1 | class I SAM-dependent methyltransferase | - |
| A4R37_RS25000 () | 12724..14085 | - | 1362 | WP_000170714.1 | DUF3560 domain-containing protein | - |
| A4R37_RS25005 () | 14137..14367 | - | 231 | WP_000218642.1 | hypothetical protein | - |
| A4R37_RS25010 () | 15402..15593 | - | 192 | WP_001027516.1 | hypothetical protein | - |
| A4R37_RS25015 () | 15590..16012 | - | 423 | WP_000271753.1 | DUF1380 family protein | - |
| A4R37_RS25020 () | 16059..16361 | - | 303 | WP_001671341.1 | antirestriction protein | - |
| A4R37_RS29660 () | 16901..17677 | - | 777 | WP_001753849.1 | hypothetical protein | - |
| A4R37_RS25030 () | 17728..18162 | - | 435 | WP_000274437.1 | DUF1380 family protein | - |
| A4R37_RS25035 () | 18176..18397 | - | 222 | WP_001104873.1 | hypothetical protein | - |
| A4R37_RS25040 () | 18398..19081 | - | 684 | WP_000086185.1 | DNA methylase | - |
| A4R37_RS28765 () | 19158..19462 | - | 305 | Protein_28 | hypothetical protein | - |
| A4R37_RS25050 () | 19466..20368 | - | 903 | WP_001348615.1 | DUF1281 domain-containing protein | - |
| A4R37_RS25055 () | 21067..22038 | - | 972 | WP_000817036.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| A4R37_RS25060 () | 22038..23204 | - | 1167 | WP_000772446.1 | Sporulation initiation inhibitor protein Soj | VF |
| A4R37_RS25065 () | 23792..24547 | - | 756 | WP_000852146.1 | replication initiation protein RepE | - |
| A4R37_RS25070 () | 25321..26127 | - | 807 | WP_000016982.1 | site-specific integrase | - |
| A4R37_RS25075 () | 26128..26433 | - | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| A4R37_RS25080 () | 26435..26653 | - | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| A4R37_RS25085 () | 27220..27732 | + | 513 | WP_000151784.1 | hypothetical protein | - |
| A4R37_RS25090 () | 27766..28899 | - | 1134 | WP_000545987.1 | DUF3800 domain-containing protein | - |
| A4R37_RS25095 () | 29066..29839 | - | 774 | WP_000905949.1 | hypothetical protein | - |
| A4R37_RS25100 () | 29852..30352 | - | 501 | WP_000528931.1 | hypothetical protein | - |
| A4R37_RS25105 () | 30617..30847 | + | 231 | WP_001261278.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin Detail |
| A4R37_RS25110 () | 30844..31260 | + | 417 | WP_001034046.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| A4R37_RS25115 () | 31305..34349 | - | 3045 | Protein_42 | pcar | - |
| A4R37_RS25120 () | 34365..35062 | - | 698 | Protein_43 | IS1 family transposase IS1R | Transposase |
| A4R37_RS25125 () | 35091..35348 | - | 258 | WP_061092170.1 | hypothetical protein | - |
| A4R37_RS25130 () | 35454..35729 | - | 276 | WP_000421272.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin Detail |
| A4R37_RS25135 () | 35729..36013 | - | 285 | WP_001387467.1 | ribbon-helix-helix domain-containing protein | Antitoxin Detail |
| A4R37_RS25140 () | 36618..37370 | + | 753 | WP_000562172.1 | IclR family transcriptional regulator | - |
| A4R37_RS25145 () | 37416..38381 | - | 966 | WP_001022265.1 | 2-keto-3-deoxygluconate transporter | - |
| A4R37_RS25150 () | 38414..38794 | - | 381 | WP_000710783.1 | Rid family detoxifying hydrolase | - |
| A4R37_RS25155 () | 38819..39709 | - | 891 | WP_001077068.1 | dihydrodipicolinate synthase family protein | - |
| A4R37_RS25160 () | 39942..40136 | - | 195 | WP_000796505.1 | hypothetical protein | - |
| A4R37_RS25165 () | 40110..40550 | + | 441 | Protein_52 | zinc-binding dehydrogenase | - |
| A4R37_RS25170 () | 40681..41559 | + | 879 | WP_000338039.1 | sugar ABC transporter permease | - |
| A4R37_RS25175 () | 41549..42436 | + | 888 | WP_001271561.1 | carbohydrate ABC transporter permease | - |
| A4R37_RS25180 () | 42447..43271 | + | 825 | WP_000922702.1 | phosphodiesterase | - |
| A4R37_RS25185 () | 43277..44350 | + | 1074 | WP_000950177.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | VF |
| A4R37_RS25190 () | 44343..45653 | + | 1311 | WP_000476108.1 | ABC transporter substrate-binding protein | - |
| A4R37_RS25195 () | 45712..46020 | - | 309 | Protein_58 | IS4 family transposase ISEc13 | Transposase |
| A4R37_RS27960 () | 46097..46330 | - | 234 | Protein_59 | Tn3 family transposase | - |
| A4R37_RS25200 () | 46352..47548 | - | 1197 | Protein_60 | IS3 family transposase | - |
| A4R37_RS25210 () | 47573..48277 | + | 705 | WP_001067834.1 | IS6 family transposase IS26 | Transposase |
| A4R37_RS25215 () | 48335..48865 | - | 531 | Protein_62 | histidine-type phosphatase | - |
| A4R37_RS25220 () | 48987..49472 | - | 486 | WP_000874189.1 | hypothetical protein | - |
| A4R37_RS25225 () | 49497..49982 | - | 486 | WP_001267177.1 | TlpA family protein disulfide reductase | - |
| A4R37_RS25230 () | 49969..50664 | - | 696 | WP_000117262.1 | Lipoprotein-releasing system ATP-binding protein LolD | VF |
| A4R37_RS25235 () | 50669..51799 | - | 1131 | WP_000729220.1 | ABC transporter permease | - |
| A4R37_RS25240 () | 51789..53072 | - | 1284 | WP_000964653.1 | ABC transporter permease | - |
| A4R37_RS25245 () | 53075..54454 | - | 1380 | WP_000119836.1 | DUF2318 domain-containing protein | - |
| A4R37_RS25250 () | 54558..55085 | - | 528 | WP_000178050.1 | iron transporter | - |
| A4R37_RS25255 () | 55126..57012 | - | 1887 | WP_000118029.1 | FTR1 family iron permease | - |
| A4R37_RS25260 () | 57359..58174 | - | 816 | WP_012372823.1 | Na(+)-translocating NADH-quinone reductase subunit C | - |
| A4R37_RS25265 () | 58357..58863 | - | 507 | WP_000949452.1 | protein disulfide oxidoreductase | - |
| A4R37_RS25270 () | 58853..59011 | - | 159 | WP_000449408.1 | DsbA family protein | - |
| A4R37_RS29815 () | 59161..59274 | - | 114 | Protein_74 | IS6 family transposase | - |
| A4R37_RS25275 () | 59474..60171 | + | 698 | Protein_75 | IS1 family transposase IS1R | Transposase |
| A4R37_RS29410 () | 60292..60420 | - | 129 | Protein_76 | IS481 family transposase | - |
| A4R37_RS25280 () | 60453..61622 | - | 1170 | WP_001072355.1 | hypothetical protein | - |
| A4R37_RS25285 () | 62115..62422 | + | 308 | Protein_78 | type II toxin-antitoxin system ParD family antitoxin | - |
| A4R37_RS29415 () | 62765..62947 | + | 183 | WP_042344623.1 | hypothetical protein | - |
| A4R37_RS25300 () | 63068..63808 | + | 741 | WP_001066953.1 | tyrosine-type recombinase/integrase | - |
| A4R37_RS25305 () | 64093..65070 | - | 978 | WP_000361611.1 | RepB family plasmid replication initiator protein | - |
| A4R37_RS25320 () | 65816..66139 | + | 324 | Protein_82 | IS21 family transposase IS21 | Transposase |
| A4R37_RS29820 () | 66141..66245 | + | 105 | Protein_83 | AAA family ATPase | - |
| A4R37_RS25325 () | 66306..66819 | + | 514 | Protein_84 | DUF4113 domain-containing protein | - |
| A4R37_RS25330 () | 66999..67696 | - | 698 | Protein_85 | IS1 family transposase IS1S | Transposase |
| A4R37_RS25335 () | 68052..68966 | + | 915 | WP_000949004.1 | Putative metal ABC transporter substrate-binding protein Hpf | VF |
| A4R37_RS25340 () | 68966..69793 | + | 828 | WP_000983710.1 | Iron(3+)-hydroxamate import ATP-binding protein FhuC | VF |
| A4R37_RS25345 () | 69790..70647 | + | 858 | WP_001101723.1 | Manganese transport system membrane protein MntB | ARG |
| A4R37_RS25350 () | 70644..71501 | + | 858 | WP_000968139.1 | Manganese transport system membrane protein MntB | ARG |
| A4R37_RS25355 () | 71900..72597 | + | 698 | Protein_90 | IS1 family transposase IS1S | Transposase |
| A4R37_RS25365 () | 72851..73873 | - | 1023 | WP_000361402.1 | helicase UvrD | - |
| A4R37_RS25370 () | 73858..75423 | - | 1566 | WP_001128474.1 | AAA family ATPase | - |
| A4R37_RS25375 () | 75498..75914 | - | 417 | WP_001034044.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| A4R37_RS25380 () | 75911..76141 | - | 231 | WP_001261286.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin Detail |
| A4R37_RS25385 () | 76522..76911 | + | 390 | Protein_95 | pcar | - |
| A4R37_RS25390 () | 76976..77215 | + | 240 | Protein_96 | IS6 family transposase IS15DII | Transposase |
| A4R37_RS25395 () | 77267..77971 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| A4R37_RS25400 () | 78035..78373 | + | 339 | Protein_98 | Tn3 family transposase TnpR_Tn3 | Transposase |
| A4R37_RS25405 () | 78556..79416 | + | 861 | WP_000027057.1 | Beta-lactamase TEM | ARG |
| A4R37_RS28010 () | 79563..79844 | + | 282 | Protein_100 | transposase zinc-binding domain-containing protein | - |
| A4R37_RS25410 () | 80014..80718 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| A4R37_RS25415 () | 80768..81487 | + | 720 | Protein_102 | AAA family ATPase | - |
| A4R37_RS25420 () | 81474..82445 | + | 972 | WP_000240537.1 | replication protein C | - |
| A4R37_RS25425 () | 82633..83448 | + | 816 | WP_001043265.1 | Dihydropteroate synthase | ARG |
| A4R37_RS25430 () | 83509..84312 | + | 804 | WP_001082319.1 | Aminoglycoside 3'-phosphotransferase | ARG |
| A4R37_RS25435 () | 84312..85148 | + | 837 | WP_000480968.1 | hypothetical protein | ARG |
| A4R37_RS25440 () | 85209..85913 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| A4R37_RS25445 () | 85978..87228 | - | 1251 | Protein_108 | transposase | - |
| A4R37_RS25450 () | 87303..87971 | - | 669 | WP_001300294.1 | putative signaling protein | VF |
| A4R37_RS25455 () | 88007..88243 | - | 237 | WP_000993386.1 | broad-spectrum mercury transporter MerE | - |
| A4R37_RS25460 () | 88240..88602 | - | 363 | WP_001277456.1 | mercury resistance co-regulator MerD | - |
| A4R37_RS25465 () | 88620..90314 | - | 1695 | WP_000105636.1 | mercury(II) reductase | - |
| A4R37_RS25470 () | 90366..90788 | - | 423 | WP_001340589.1 | organomercurial transporter MerC | - |
| A4R37_RS25475 () | 90824..91099 | - | 276 | WP_000732292.1 | mercury resistance system periplasmic binding protein MerP | - |
| A4R37_RS25480 () | 91113..91463 | - | 351 | WP_001294663.1 | mercuric transport protein MerT | - |
| A4R37_RS25485 () | 91535..91969 | + | 435 | WP_000429836.1 | IS607 family transposase ISChh1 | Transposase |
| A4R37_RS25490 () | 92075..92772 | - | 698 | Protein_117 | IS1 family transposase IS1R | Transposase |
| A4R37_RS25495 () | 93205..93606 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| A4R37_RS29665 () | 93539..93796 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| A4R37_RS25505 () | 93889..94542 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| A4R37_RS25510 () | 95400..97013 | - | 1614 | WP_000080200.1 | IS66 family transposase ISEc23 | Transposase |
| A4R37_RS25515 () | 97044..97394 | - | 351 | WP_000624722.1 | IS66 family transposase ISEc23 | Transposase |
| A4R37_RS25520 () | 97391..97816 | - | 426 | WP_000422741.1 | IS66 family transposase ISEc23 | Transposase |
| A4R37_RS25525 () | 98022..98879 | - | 858 | WP_000130640.1 | incFII family plasmid replication initiator RepA | - |
| A4R37_RS25530 () | 98872..98946 | - | 75 | WP_031943482.1 | RepA leader peptide Tap | - |
| A4R37_RS29825 () | 98943..99077 | - | 135 | Protein_126 | protein CopA/IncA | - |
| A4R37_RS25535 () | 99183..99437 | - | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
| A4R37_RS25540 () | 99734..99868 | - | 135 | WP_023144756.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| - () | 99913..99973 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 99913..99973 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 99913..99973 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 99913..99973 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| A4R37_RS25545 () | 99940..100226 | - | 287 | Protein_129 | DUF2726 domain-containing protein | - |
| A4R37_RS25550 () | 100739..100951 | - | 213 | WP_013023861.1 | hypothetical protein | - |
| A4R37_RS25555 () | 101082..101642 | - | 561 | WP_000139341.1 | fertility inhibition protein FinO | - |
| A4R37_RS25560 () | 101697..102443 | - | 747 | WP_000205718.1 | conjugal transfer pilus acetylase TraX | - |
| A4R37_RS25565 () | 102463..107733 | - | 5271 | WP_001617867.1 | Multifunctional conjugation protein TraI | Relaxase |
| A4R37_RS25570 () | 107733..109949 | - | 2217 | WP_023356304.1 | type IV conjugative transfer system coupling protein TraD | - |
| A4R37_RS28815 () | 109946..110530 | - | 585 | WP_077759813.1 | hypothetical protein | - |
| A4R37_RS25580 () | 110927..111658 | - | 732 | WP_000850429.1 | complement resistance protein TraT | - |
| A4R37_RS25585 () | 111690..112187 | - | 498 | WP_000605862.1 | entry exclusion protein | - |
| A4R37_RS25590 () | 112206..115025 | - | 2820 | WP_001007062.1 | conjugal transfer mating pair stabilization protein TraG | - |
| A4R37_RS25595 () | 115022..116395 | - | 1374 | WP_000944328.1 | conjugal transfer protein TraH | - |
| A4R37_RS25600 () | 116382..116807 | - | 426 | WP_001348758.1 | F-type conjugal transfer protein TrbF | - |
| A4R37_RS25605 () | 116755..117102 | - | 348 | WP_071571857.1 | P-type conjugative transfer protein TrbJ | - |
| A4R37_RS25610 () | 117032..117577 | - | 546 | WP_000059829.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| A4R37_RS25615 () | 117564..117848 | - | 285 | WP_001617873.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| A4R37_RS25620 () | 117975..118295 | - | 321 | WP_001348757.1 | conjugal transfer protein TrbA | - |
| A4R37_RS25625 () | 118343..119040 | - | 698 | Protein_145 | IS1 family transposase IS1G | Transposase |
| A4R37_RS25630 () | 119195..120175 | - | 981 | WP_000019450.1 | IS5 family transposase ISKpn26 | Transposase |
| A4R37_RS25635 () | 120305..121048 | - | 744 | WP_001030401.1 | type-F conjugative transfer system pilin assembly protein TraF | - |
| A4R37_RS25640 () | 121041..121298 | - | 258 | WP_000864347.1 | conjugal transfer protein TrbE | - |
| A4R37_RS25645 () | 121325..123175 | - | 1851 | WP_000821866.1 | type-F conjugative transfer system mating-pair stabilization protein TraN | - |
| A4R37_RS25650 () | 123172..123810 | - | 639 | WP_001080259.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| A4R37_RS25655 () | 123819..124124 | - | 306 | WP_000224413.1 | hypothetical protein | - |
| A4R37_RS25660 () | 124154..125146 | - | 993 | WP_000830190.1 | conjugal transfer pilus assembly protein TraU | - |
| A4R37_RS25665 () | 125143..125775 | - | 633 | WP_001203727.1 | type-F conjugative transfer system protein TraW | - |
| A4R37_RS25670 () | 125772..126158 | - | 387 | WP_000214084.1 | type-F conjugative transfer system protein TrbI | - |
| A4R37_RS25675 () | 126155..128782 | - | 2628 | WP_001064258.1 | type IV secretion system protein TraC | - |
| A4R37_RS28070 () | 128942..129163 | - | 222 | WP_001278694.1 | conjugal transfer protein TraR | - |
| A4R37_RS25680 () | 129298..129813 | - | 516 | WP_000809886.1 | type IV conjugative transfer system lipoprotein TraV | - |
| A4R37_RS25685 () | 129813..130172 | - | 360 | WP_001617876.1 | conjugal transfer protein TrbD | - |
| A4R37_RS25690 () | 130111..130698 | - | 588 | WP_071587349.1 | conjugal transfer protein TraP | - |
| A4R37_RS25695 () | 130667..132118 | - | 1452 | WP_000146687.1 | conjugal transfer protein TraB | - |
| A4R37_RS25700 () | 132118..132822 | - | 705 | WP_148725207.1 | type-F conjugative transfer system secretin TraK | - |
| A4R37_RS25705 () | 132833..133398 | - | 566 | Protein_162 | type IV conjugative transfer system protein TraE | - |
| A4R37_RS25710 () | 133420..133731 | - | 312 | WP_000012107.1 | type IV conjugative transfer system protein TraL | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|