Detailed information NTG0998936

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ABD407_RS00335
• Genome accession: NZ_CP155736
• Coordinates: 52872..53783 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 1966/14
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47872..58783

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD407_RS00315 (ABD407_00310)	purE	48458..48949 (+)	492	WP_023612097.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ABD407_RS00320 (ABD407_00315)	purK	48936..50009 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ABD407_RS00325 (ABD407_00320)	-	50011..51429 (+)	1419	WP_023612101.1	hypothetical protein	-
ABD407_RS00330 (ABD407_00325)	purB	51449..52741 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
ABD407_RS00335 (ABD407_00330)	comR	52872..53783 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
ABD407_RS00340	comS	53863..53961 (+)	99	WP_206733287.1	quorum-sensing system DWW-type pheromone	Regulator
ABD407_RS00345 (ABD407_00335)	ruvB	54008..55006 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
ABD407_RS00350 (ABD407_00340)	-	55144..55581 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
ABD407_RS00355 (ABD407_00345)	-	55604..56005 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ABD407_RS00360 (ABD407_00350)	-	56002..57777 (+)	1776	WP_023612103.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=998936 ABD407_RS00335 WP_002986681.1 52872..53783(+) (comR) [Streptococcus pyogenes strain 1966/14]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=998936 ABD407_RS00335 WP_002986681.1 52872..53783(+) (comR) [Streptococcus pyogenes strain 1966/14]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462