Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   ABC804_RS02700 Genome accession   NZ_CP155536
Coordinates   483205..483864 (-) Length   219 a.a.
NCBI ID   WP_000565024.1    Uniprot ID   A0A4J1XTA1
Organism   Streptococcus pneumoniae strain M264-3     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 465577..492901 483205..483864 within 0


Gene organization within MGE regions


Location: 465577..492901
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC804_RS02600 (ABC804_02600) - 465577..465873 (+) 297 WP_000239034.1 hypothetical protein -
  ABC804_RS02605 (ABC804_02605) - 466121..466405 (+) 285 Protein_457 GDP-mannose 4,6-dehydratase -
  ABC804_RS02610 (ABC804_02610) - 466614..467273 (+) 660 WP_000793815.1 DUF1868 domain-containing protein -
  ABC804_RS02615 (ABC804_02615) - 467298..468365 (+) 1068 WP_000738372.1 extracellular solute-binding protein -
  ABC804_RS02620 (ABC804_02620) - 468468..469478 (+) 1011 WP_000589142.1 ABC transporter ATP-binding protein -
  ABC804_RS02625 (ABC804_02625) - 469490..471181 (+) 1692 WP_001216185.1 iron ABC transporter permease -
  ABC804_RS02630 (ABC804_02630) - 471184..471894 (+) 711 WP_000127552.1 MgtC/SapB family protein -
  ABC804_RS02635 (ABC804_02635) - 471990..472358 (+) 369 WP_000656294.1 hypothetical protein -
  ABC804_RS02640 (ABC804_02640) - 472466..473467 (+) 1002 WP_000789949.1 LacI family DNA-binding transcriptional regulator -
  ABC804_RS02645 (ABC804_02645) - 474072..474323 (+) 252 WP_000693082.1 hypothetical protein -
  ABC804_RS02650 (ABC804_02650) trpE 474695..476056 (+) 1362 WP_363860701.1 anthranilate synthase component I -
  ABC804_RS02655 (ABC804_02655) - 476053..476619 (+) 567 WP_000601926.1 aminodeoxychorismate/anthranilate synthase component II -
  ABC804_RS02660 (ABC804_02660) trpD 476630..477634 (+) 1005 WP_000658684.1 anthranilate phosphoribosyltransferase -
  ABC804_RS02665 (ABC804_02665) trpC 477631..478398 (+) 768 WP_000076548.1 indole-3-glycerol phosphate synthase TrpC -
  ABC804_RS02670 (ABC804_02670) - 478385..478984 (+) 600 WP_000169899.1 phosphoribosylanthranilate isomerase -
  ABC804_RS02675 (ABC804_02675) trpB 478962..480185 (+) 1224 WP_000331297.1 tryptophan synthase subunit beta -
  ABC804_RS02680 (ABC804_02680) trpA 480178..480954 (+) 777 WP_001127028.1 tryptophan synthase subunit alpha -
  ABC804_RS02685 (ABC804_02685) - 480926..481027 (-) 102 Protein_473 prepilin peptidase -
  ABC804_RS02690 (ABC804_02690) - 481256..481987 (+) 732 WP_000934017.1 hypothetical protein -
  ABC804_RS02695 (ABC804_02695) - 482002..483153 (+) 1152 WP_000481758.1 XRE family transcriptional regulator -
  ABC804_RS02700 (ABC804_02700) cclA/cilC 483205..483864 (-) 660 WP_000565024.1 A24 family peptidase Machinery gene
  ABC804_RS02705 (ABC804_02705) - 483934..484380 (+) 447 WP_000155412.1 GNAT family N-acetyltransferase -
  ABC804_RS02710 (ABC804_02710) - 484608..485786 (-) 1179 WP_000175878.1 ROK family transcriptional regulator -
  ABC804_RS02715 (ABC804_02715) - 486066..487328 (+) 1263 WP_000413345.1 PTS sugar transporter subunit IIC -
  ABC804_RS02720 (ABC804_02720) - 487331..488227 (+) 897 WP_000825665.1 PEP phosphonomutase -
  ABC804_RS02725 (ABC804_02725) - 488242..488559 (+) 318 WP_001151646.1 PTS sugar transporter subunit IIB -
  ABC804_RS02730 (ABC804_02730) - 488576..488893 (+) 318 WP_000344534.1 PTS lactose/cellobiose transporter subunit IIA -
  ABC804_RS02735 (ABC804_02735) - 488903..490258 (+) 1356 WP_001094994.1 PTS sugar transporter subunit IIC -
  ABC804_RS02740 (ABC804_02740) - 490581..492056 (+) 1476 WP_000250879.1 arylsulfatase -
  ABC804_RS02745 (ABC804_02745) - 492053..492901 (+) 849 WP_000782429.1 formylglycine-generating enzyme family protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24951.16 Da        Isoelectric Point: 8.2409

>NTDB_id=997420 ABC804_RS02700 WP_000565024.1 483205..483864(-) (cclA/cilC) [Streptococcus pneumoniae strain M264-3]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILITSSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=997420 ABC804_RS02700 WP_000565024.1 483205..483864(-) (cclA/cilC) [Streptococcus pneumoniae strain M264-3]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAACTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1XTA1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae Rx1

95.434

100

0.954
  cclA/cilC Streptococcus pneumoniae D39

95.434

100

0.954
  cclA/cilC Streptococcus pneumoniae R6

95.434

100

0.954
  cclA/cilC Streptococcus mitis SK321

91.324

100

0.913
  cclA/cilC Streptococcus mitis NCTC 12261

85.388

100

0.854

Multiple sequence alignment