Detailed information NTG0997332

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ABC811_RS07740
• Genome accession: NZ_CP155535
• Coordinates: 1495153..1495890 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219141.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PJ755/1
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1490153..1500890

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC811_RS07720 (ABC811_07715)	comA/nlmT	1490681..1492171 (+)	1491	WP_001818755.1	peptide cleavage/export ABC transporter	Regulator
ABC811_RS07725 (ABC811_07720)	-	1492182..1493543 (+)	1362	WP_001069071.1	bacteriocin secretion accessory protein	-
ABC811_RS07730 (ABC811_07725)	blpC	1493600..1493755 (+)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
ABC811_RS07735 (ABC811_07730)	-	1493799..1495139 (-)	1341	WP_001099892.1	sensor histidine kinase	-
ABC811_RS07740 (ABC811_07735)	comE/blpR	1495153..1495890 (-)	738	WP_001219141.1	response regulator transcription factor	Regulator
ABC811_RS07745 (ABC811_07740)	-	1495895..1496233 (-)	339	WP_000682133.1	LytTR family DNA-binding domain-containing protein	-
ABC811_RS07750 (ABC811_07745)	-	1496510..1496839 (+)	330	WP_000132572.1	hypothetical protein	-
ABC811_RS07755 (ABC811_07750)	-	1497007..1498056 (-)	1050	WP_000653751.1	ABC transporter permease	-
ABC811_RS07760 (ABC811_07755)	pptA	1498053..1498784 (-)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
ABC811_RS07765 (ABC811_07760)	-	1498852..1499262 (+)	411	WP_001278304.1	HIT family protein	-
ABC811_RS07770 (ABC811_07765)	-	1499272..1499559 (+)	288	WP_000777753.1	hypothetical protein	-
ABC811_RS07775 (ABC811_07770)	-	1499721..1499960 (+)	240	WP_001813906.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.87 Da
• Isoelectric Point: 6.2366

>NTDB_id=997332 ABC811_RS07740 WP_001219141.1 1495153..1495890(-) (comE/blpR) [Streptococcus pneumoniae strain PJ755/1]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=997332 ABC811_RS07740 WP_001219141.1 1495153..1495890(-) (comE/blpR) [Streptococcus pneumoniae strain PJ755/1]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.441	100	0.539
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38