Detailed information NTG0997286

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ABC799_RS08510
• Genome accession: NZ_CP155534
• Coordinates: 1630652..1631389 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain DCC1476
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1625652..1636389

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC799_RS08490 (ABC799_08490)	comA/nlmT	1626029..1627672 (+)	1644	WP_078133841.1	peptide cleavage/export ABC transporter	Regulator
ABC799_RS08495 (ABC799_08495)	-	1627683..1629044 (+)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
ABC799_RS08500 (ABC799_08500)	blpC	1629101..1629256 (+)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
ABC799_RS08505 (ABC799_08505)	-	1629298..1630638 (-)	1341	WP_001017638.1	sensor histidine kinase	-
ABC799_RS08510 (ABC799_08510)	comE/blpR	1630652..1631389 (-)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
ABC799_RS08515 (ABC799_08515)	-	1631394..1631732 (-)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
ABC799_RS08520 (ABC799_08520)	-	1632009..1632338 (+)	330	WP_000132572.1	hypothetical protein	-
ABC799_RS08525 (ABC799_08525)	-	1632506..1633555 (-)	1050	WP_000653767.1	ABC transporter permease	-
ABC799_RS08530 (ABC799_08530)	pptA	1633552..1634283 (-)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
ABC799_RS08535 (ABC799_08535)	-	1634351..1634761 (+)	411	WP_001278299.1	HIT family protein	-
ABC799_RS08540 (ABC799_08540)	-	1634771..1635058 (+)	288	WP_000777760.1	hypothetical protein	-
ABC799_RS08545 (ABC799_08545)	-	1635220..1635459 (+)	240	WP_001810235.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=997286 ABC799_RS08510 WP_001219120.1 1630652..1631389(-) (comE/blpR) [Streptococcus pneumoniae strain DCC1476]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=997286 ABC799_RS08510 WP_001219120.1 1630652..1631389(-) (comE/blpR) [Streptococcus pneumoniae strain DCC1476]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363