Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   ABC814_RS08990 Genome accession   NZ_CP155533
Coordinates   1755523..1756182 (+) Length   219 a.a.
NCBI ID   WP_000565007.1    Uniprot ID   A0A4J1VGV4
Organism   Streptococcus pneumoniae strain Spn1439-106     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1750523..1761182
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC814_RS08955 (ABC814_08955) mgaSpn 1751133..1752614 (-) 1482 WP_001205281.1 virulence factor transcriptional regulator MgaSpn -
  ABC814_RS08960 (ABC814_08960) - 1753057..1753221 (+) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  ABC814_RS08965 (ABC814_08965) amaP 1753305..1753871 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  ABC814_RS08970 (ABC814_08970) - 1753883..1754053 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  ABC814_RS08975 (ABC814_08975) - 1754092..1754700 (+) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  ABC814_RS08980 (ABC814_08980) - 1754731..1754934 (+) 204 WP_000109956.1 CsbD family protein -
  ABC814_RS08985 (ABC814_08985) - 1755007..1755453 (-) 447 WP_000155417.1 GNAT family protein -
  ABC814_RS08990 (ABC814_08990) cclA/cilC 1755523..1756182 (+) 660 WP_000565007.1 A24 family peptidase Machinery gene
  ABC814_RS08995 (ABC814_08995) - 1756234..1757385 (-) 1152 WP_000481756.1 XRE family transcriptional regulator -
  ABC814_RS09000 (ABC814_09000) - 1757400..1758131 (-) 732 WP_000934016.1 hypothetical protein -
  ABC814_RS09005 (ABC814_09005) - 1758360..1758461 (+) 102 Protein_1783 prepilin peptidase -
  ABC814_RS09010 (ABC814_09010) trpA 1758433..1759209 (-) 777 WP_001127026.1 tryptophan synthase subunit alpha -
  ABC814_RS09015 (ABC814_09015) trpB 1759202..1760425 (-) 1224 WP_000331291.1 tryptophan synthase subunit beta -
  ABC814_RS09020 (ABC814_09020) - 1760403..1761002 (-) 600 WP_061645124.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24761.83 Da        Isoelectric Point: 7.5762

>NTDB_id=997179 ABC814_RS08990 WP_000565007.1 1755523..1756182(+) (cclA/cilC) [Streptococcus pneumoniae strain Spn1439-106]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACGIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=997179 ABC814_RS08990 WP_000565007.1 1755523..1756182(+) (cclA/cilC) [Streptococcus pneumoniae strain Spn1439-106]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGTAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAGAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGGGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1VGV4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

99.087

100

0.991
  cclA/cilC Streptococcus pneumoniae D39

99.087

100

0.991
  cclA/cilC Streptococcus pneumoniae R6

99.087

100

0.991
  cclA/cilC Streptococcus pneumoniae TIGR4

94.521

100

0.945
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

87.215

100

0.872

Multiple sequence alignment