Detailed information NTG0994433

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: AAYT23_RS02285
• Genome accession: NZ_CP154877
• Coordinates: 444761..445498 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219122.1
• Uniprot ID: A0A0I5XJR5
• Organism: Streptococcus pneumoniae strain 20234295
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 439761..450498

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAYT23_RS02250 (AAYT23_02235)	-	440737..440931 (-)	195	WP_001808905.1	hypothetical protein	-
AAYT23_RS02255 (AAYT23_02240)	-	441093..441380 (-)	288	WP_000777760.1	hypothetical protein	-
AAYT23_RS02260 (AAYT23_02245)	-	441390..441800 (-)	411	WP_001278301.1	HIT family protein	-
AAYT23_RS02265 (AAYT23_02250)	pptA	441868..442599 (+)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
AAYT23_RS02270 (AAYT23_02255)	-	442596..443645 (+)	1050	WP_000653771.1	ABC transporter permease	-
AAYT23_RS02275 (AAYT23_02260)	-	443813..444142 (-)	330	WP_000132572.1	hypothetical protein	-
AAYT23_RS02280 (AAYT23_02265)	-	444418..444756 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
AAYT23_RS02285 (AAYT23_02270)	comE/blpR	444761..445498 (+)	738	WP_001219122.1	response regulator transcription factor	Regulator
AAYT23_RS02290 (AAYT23_02275)	-	445512..446852 (+)	1341	WP_001017622.1	sensor histidine kinase	-
AAYT23_RS02295 (AAYT23_02280)	blpC	446894..447049 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
AAYT23_RS02300 (AAYT23_02285)	-	447106..448467 (-)	1362	WP_001069074.1	bacteriocin secretion accessory protein	-
AAYT23_RS02305 (AAYT23_02290)	comA/nlmT	448478..449125 (-)	648	WP_078064020.1	ATP-binding cassette domain-containing protein	Regulator
AAYT23_RS02310 (AAYT23_02295)	comA/nlmT	449141..450154 (-)	1014	WP_318528993.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28766.95 Da
• Isoelectric Point: 6.4140

>NTDB_id=994433 AAYT23_RS02285 WP_001219122.1 444761..445498(+) (comE/blpR) [Streptococcus pneumoniae strain 20234295]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=994433 AAYT23_RS02285 WP_001219122.1 444761..445498(+) (comE/blpR) [Streptococcus pneumoniae strain 20234295]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0I5XJR5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38