Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   AAHH81_RS08045 Genome accession   NZ_CP152418
Coordinates   1598570..1599229 (+) Length   219 a.a.
NCBI ID   WP_000565010.1    Uniprot ID   A0A0B7M2C6
Organism   Streptococcus pneumoniae strain 20234287     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1593570..1604229
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAHH81_RS08005 (AAHH81_07990) mgaSpn 1593717..1595207 (-) 1491 WP_061813617.1 virulence factor transcriptional regulator MgaSpn -
  AAHH81_RS08010 (AAHH81_07995) - 1595650..1595814 (+) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  AAHH81_RS08015 (AAHH81_08000) amaP 1595898..1596464 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  AAHH81_RS08020 (AAHH81_08005) - 1596476..1596646 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  AAHH81_RS08025 (AAHH81_08010) - 1596685..1597293 (+) 609 WP_061640415.1 Asp23/Gls24 family envelope stress response protein -
  AAHH81_RS08030 (AAHH81_08015) - 1597324..1597527 (+) 204 WP_000109957.1 CsbD family protein -
  AAHH81_RS08035 (AAHH81_08020) - 1597637..1597909 (-) 273 Protein_1588 transposase -
  AAHH81_RS08040 (AAHH81_08025) - 1598054..1598500 (-) 447 WP_000155430.1 GNAT family N-acetyltransferase -
  AAHH81_RS08045 (AAHH81_08030) cclA/cilC 1598570..1599229 (+) 660 WP_000565010.1 prepilin peptidase Machinery gene
  AAHH81_RS08050 (AAHH81_08035) - 1599281..1600432 (-) 1152 WP_000481756.1 XRE family transcriptional regulator -
  AAHH81_RS08055 (AAHH81_08040) - 1600447..1601178 (-) 732 WP_000934018.1 hypothetical protein -
  AAHH81_RS08060 (AAHH81_08045) - 1601398..1601508 (+) 111 Protein_1593 prepilin peptidase -
  AAHH81_RS08065 (AAHH81_08050) trpA 1601480..1602256 (-) 777 WP_001127044.1 tryptophan synthase subunit alpha -
  AAHH81_RS08070 (AAHH81_08055) trpB 1602249..1603472 (-) 1224 WP_000331292.1 tryptophan synthase subunit beta -
  AAHH81_RS08075 (AAHH81_08060) - 1603450..1604049 (-) 600 WP_000169913.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24845.99 Da        Isoelectric Point: 7.5762

>NTDB_id=989081 AAHH81_RS08045 WP_000565010.1 1598570..1599229(+) (cclA/cilC) [Streptococcus pneumoniae strain 20234287]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=989081 AAHH81_RS08045 WP_000565010.1 1598570..1599229(+) (cclA/cilC) [Streptococcus pneumoniae strain 20234287]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M2C6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

100

100

1
  cclA/cilC Streptococcus pneumoniae D39

100

100

1
  cclA/cilC Streptococcus pneumoniae R6

100

100

1
  cclA/cilC Streptococcus pneumoniae TIGR4

94.977

100

0.95
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

87.671

100

0.877

Multiple sequence alignment