Detailed information NTG0098828

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: R8568_RS08440
• Genome accession: NZ_AP026931
• Coordinates: 1671360..1672019 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565010.1
• Uniprot ID: A0A0B7M2C6
• Organism: Streptococcus pneumoniae strain PZ900701541
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1666360..1677019

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8568_RS08415 (PC1520_16680)	-	1666665..1666982 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
R8568_RS08420 (PC1520_16690)	-	1666997..1667893 (-)	897	WP_000825669.1	PEP phosphonomutase	-
R8568_RS08425 (PC1520_16700)	-	1667896..1669158 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
R8568_RS08430 (PC1520_16710)	-	1669438..1670616 (+)	1179	WP_000175876.1	ROK family transcriptional regulator	-
R8568_RS08435 (PC1520_16720)	-	1670844..1671290 (-)	447	WP_000155418.1	GNAT family N-acetyltransferase	-
R8568_RS08440 (PC1520_16730)	cclA/cilC	1671360..1672019 (+)	660	WP_000565010.1	A24 family peptidase	Machinery gene
R8568_RS08445 (PC1520_16740)	trpA	1671991..1672767 (-)	777	WP_001126994.1	tryptophan synthase subunit alpha	-
R8568_RS08450 (PC1520_16750)	trpB	1672760..1673983 (-)	1224	WP_000331292.1	tryptophan synthase subunit beta	-
R8568_RS08455 (PC1520_16760)	-	1673961..1674560 (-)	600	WP_317640055.1	phosphoribosylanthranilate isomerase	-
R8568_RS08460 (PC1520_16770)	trpC	1674547..1675314 (-)	768	WP_000076558.1	indole-3-glycerol phosphate synthase TrpC	-
R8568_RS08465 (PC1520_16780)	trpD	1675311..1676315 (-)	1005	WP_000658684.1	anthranilate phosphoribosyltransferase	-
R8568_RS08470 (PC1520_16790)	-	1676326..1676892 (-)	567	WP_000601927.1	aminodeoxychorismate/anthranilate synthase component II	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24845.99 Da
• Isoelectric Point: 7.5762

>NTDB_id=98828 R8568_RS08440 WP_000565010.1 1671360..1672019(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900701541]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=98828 R8568_RS08440 WP_000565010.1 1671360..1672019(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900701541]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGTAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M2C6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	100	100	1
cclA/cilC	Streptococcus pneumoniae D39	100	100	1
cclA/cilC	Streptococcus pneumoniae R6	100	100	1
cclA/cilC	Streptococcus pneumoniae TIGR4	94.977	100	0.95
cclA/cilC	Streptococcus mitis SK321	92.694	100	0.927
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877