Detailed information NTG0098755

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: R8624_RS08110
• Genome accession: NZ_AP026930
• Coordinates: 1597922..1598581 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565001.1
• Uniprot ID: A0A0B7M7B9
• Organism: Streptococcus pneumoniae strain PZ900701208
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1588884..1600530	1597922..1598581	within	0

Gene organization within MGE regions

Location: 1588884..1600530

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8624_RS08065 (PC1195_15930)	-	1588884..1589732 (-)	849	WP_000782425.1	formylglycine-generating enzyme family protein	-
R8624_RS08070 (PC1195_15940)	-	1589729..1591204 (-)	1476	WP_050096564.1	arylsulfatase	-
R8624_RS08075 (PC1195_15950)	-	1591528..1592883 (-)	1356	WP_001094994.1	PTS sugar transporter subunit IIC	-
R8624_RS08080 (PC1195_15960)	-	1592893..1593210 (-)	318	WP_050239156.1	PTS lactose/cellobiose transporter subunit IIA	-
R8624_RS08085 (PC1195_15970)	-	1593227..1593544 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
R8624_RS08090 (PC1195_15980)	-	1593559..1594455 (-)	897	WP_050198591.1	PEP phosphonomutase	-
R8624_RS08095 (PC1195_15990)	-	1594458..1595720 (-)	1263	WP_050311690.1	PTS sugar transporter subunit IIC	-
R8624_RS08100 (PC1195_16000)	-	1596000..1597178 (+)	1179	WP_050095799.1	ROK family transcriptional regulator	-
R8624_RS08105 (PC1195_16010)	-	1597406..1597852 (-)	447	WP_050084675.1	GNAT family N-acetyltransferase	-
R8624_RS08110 (PC1195_16020)	cclA/cilC	1597922..1598581 (+)	660	WP_000565001.1	A24 family peptidase	Machinery gene
R8624_RS08115 (PC1195_16030)	-	1598633..1599784 (-)	1152	WP_000481756.1	XRE family transcriptional regulator	-
R8624_RS08120 (PC1195_16040)	-	1599799..1600530 (-)	732	WP_000934017.1	hypothetical protein	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24820.92 Da
• Isoelectric Point: 7.2761

>NTDB_id=98755 R8624_RS08110 WP_000565001.1 1597922..1598581(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900701208]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=98755 R8624_RS08110 WP_000565001.1 1597922..1598581(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900701208]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
ATACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M7B9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	98.174	100	0.982
cclA/cilC	Streptococcus pneumoniae Rx1	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae D39	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae R6	96.804	100	0.968
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	87.215	100	0.872