Detailed information NTG0098649

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8615_RS02445
• Genome accession: NZ_AP026929
• Coordinates: 470998..471735 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain PZ900701114
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 465998..476735

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8615_RS02410	-	466974..467168 (-)	195	WP_001808905.1	hypothetical protein	-
R8615_RS02415 (PC1101_04810)	-	467330..467617 (-)	288	WP_000777753.1	hypothetical protein	-
R8615_RS02420 (PC1101_04820)	-	467627..468037 (-)	411	WP_001278301.1	HIT family protein	-
R8615_RS02425 (PC1101_04830)	pptA	468105..468836 (+)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
R8615_RS02430 (PC1101_04840)	-	468833..469882 (+)	1050	WP_000653771.1	ABC transporter permease	-
R8615_RS02435 (PC1101_04850)	-	470050..470379 (-)	330	WP_000132572.1	hypothetical protein	-
R8615_RS02440 (PC1101_04860)	-	470655..470993 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
R8615_RS02445 (PC1101_04870)	comE/blpR	470998..471735 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
R8615_RS02450 (PC1101_04880)	-	471749..473089 (+)	1341	WP_001017642.1	sensor histidine kinase	-
R8615_RS02455 (PC1101_04890)	blpC	473160..473288 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8615_RS02460 (PC1101_04900)	-	473345..474706 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
R8615_RS02465 (PC1101_04910)	comA/nlmT	474717..476393 (-)	1677	WP_215729172.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=98649 R8615_RS02445 WP_001219120.1 470998..471735(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900701114]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=98649 R8615_RS02445 WP_001219120.1 470998..471735(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900701114]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363