Detailed information    

insolico Bioinformatically predicted

Overview

Name   comW   Type   Regulator
Locus tag   R8615_RS00115 Genome accession   NZ_AP026929
Coordinates   22169..22405 (+) Length   78 a.a.
NCBI ID   WP_317647640.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900701114     
Function   stabilization and activation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 12175..44284 22169..22405 within 0
IScluster/Tn 20225..21852 22169..22405 flank 317


Gene organization within MGE regions


Location: 12175..44284
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8615_RS00065 (PC1101_00130) ftsH 12175..14133 (+) 1959 WP_000744557.1 ATP-dependent zinc metalloprotease FtsH -
  R8615_RS00070 (PC1101_00140) comX/comX2 14255..14734 (+) 480 WP_000588925.1 sigma-70 family RNA polymerase sigma factor Regulator
  R8615_RS00105 - 20225..21071 (+) 847 Protein_14 IS630 family transposase -
  R8615_RS00110 - 21106..21903 (-) 798 Protein_15 transposase -
  R8615_RS00115 (PC1101_00180) comW 22169..22405 (+) 237 WP_317647640.1 sigma(X)-activator ComW Regulator
  R8615_RS00120 (PC1101_00190) - 22636..23922 (+) 1287 WP_000205044.1 adenylosuccinate synthase -
  R8615_RS00125 (PC1101_00200) tadA 24123..24590 (+) 468 WP_000291870.1 tRNA adenosine(34) deaminase TadA -
  R8615_RS00135 (PC1101_00210) - 24799..25497 (-) 699 WP_001106362.1 site-specific integrase -
  R8615_RS00140 (PC1101_00220) - 25587..25934 (-) 348 WP_001839379.1 hypothetical protein -
  R8615_RS00145 (PC1101_00230) - 25995..27065 (-) 1071 WP_000401841.1 type I restriction endonuclease -
  R8615_RS00150 (PC1101_00240) - 27082..27462 (-) 381 WP_000170931.1 ImmA/IrrE family metallo-endopeptidase -
  R8615_RS00155 (PC1101_00250) - 27475..27738 (-) 264 WP_000285962.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R8615_RS00160 (PC1101_00260) - 27738..27971 (-) 234 WP_000156419.1 hypothetical protein -
  R8615_RS00165 (PC1101_00270) - 27971..28339 (-) 369 WP_000464160.1 helix-turn-helix domain-containing protein -
  R8615_RS00170 (PC1101_00290) - 28911..29102 (+) 192 WP_001112859.1 DNA-binding protein -
  R8615_RS00175 (PC1101_00300) - 29125..29328 (+) 204 WP_001247549.1 hypothetical protein -
  R8615_RS00180 (PC1101_00320) - 29483..29650 (-) 168 WP_000024181.1 YjzC family protein -
  R8615_RS00185 (PC1101_00330) - 29655..30035 (+) 381 Protein_29 autolysin -
  R8615_RS00190 (PC1101_00340) - 30255..30434 (-) 180 WP_001209433.1 hypothetical protein -
  R8615_RS00195 (PC1101_00350) - 30576..30725 (-) 150 WP_001030863.1 hypothetical protein -
  R8615_RS00200 (PC1101_00360) - 31030..31473 (+) 444 WP_000701992.1 dUTP diphosphatase -
  R8615_RS00205 (PC1101_00370) - 31475..31990 (+) 516 WP_000691236.1 histidine phosphatase family protein -
  R8615_RS00210 (PC1101_00380) radA 32004..33365 (+) 1362 WP_075213698.1 DNA repair protein RadA Machinery gene
  R8615_RS00215 (PC1101_00390) - 33438..33935 (+) 498 WP_001809263.1 carbonic anhydrase -
  R8615_RS00220 (PC1101_00400) - 33960..34743 (+) 784 Protein_36 PrsW family glutamic-type intramembrane protease -
  R8615_RS00225 (PC1101_00410) - 34888..35856 (+) 969 WP_000010157.1 ribose-phosphate diphosphokinase -
  R8615_RS00230 - 35990..36271 (-) 282 Protein_38 transposase family protein -
  R8615_RS00235 - 36398..37280 (-) 883 Protein_39 Rpn family recombination-promoting nuclease/putative transposase -
  R8615_RS00240 (PC1101_00440) polA 37536..40169 (+) 2634 WP_024477951.1 DNA polymerase I -
  R8615_RS00245 (PC1101_00450) - 40254..40691 (+) 438 WP_000076479.1 CoA-binding protein -
  R8615_RS00250 (PC1101_00460) - 40732..41160 (+) 429 WP_317647650.1 hypothetical protein -
  R8615_RS00255 (PC1101_00470) - 41189..42199 (-) 1011 WP_000009170.1 YeiH family protein -
  R8615_RS00260 (PC1101_00480) - 42348..43517 (+) 1170 WP_000366342.1 pyridoxal phosphate-dependent aminotransferase -
  R8615_RS00265 (PC1101_00490) recO 43514..44284 (+) 771 WP_000616164.1 DNA repair protein RecO -

Sequence

Protein


Download         Length: 78 a.a.        Molecular weight: 9701.11 Da        Isoelectric Point: 6.4701

>NTDB_id=98638 R8615_RS00115 WP_317647640.1 22169..22405(+) (comW) [Streptococcus pneumoniae strain PZ900701114]
MLQKIYEQMANFYDSIEEEYGPTFGDNFDWEHVHFKFFIYYLVRYGIGCHRDFIVYHYRVAYRLYLEKLVMNRGFISC

Nucleotide


Download         Length: 237 bp        

>NTDB_id=98638 R8615_RS00115 WP_317647640.1 22169..22405(+) (comW) [Streptococcus pneumoniae strain PZ900701114]
ATGTTACAAAAAATTTATGAGCAGATGGCTAATTTCTATGATAGTATTGAAGAAGAGTATGGTCCTACATTTGGTGATAA
TTTTGACTGGGAACATGTTCATTTTAAATTTTTTATTTATTATTTAGTGAGATATGGCATTGGTTGTCATAGGGATTTTA
TCGTTTACCATTATCGTGTTGCTTATCGTTTGTATCTTGAAAAATTGGTAATGAATCGGGGTTTTATTTCTTGTTGA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comW Streptococcus pneumoniae Rx1

96.154

100

0.962
  comW Streptococcus pneumoniae D39

96.154

100

0.962
  comW Streptococcus pneumoniae R6

96.154

100

0.962
  comW Streptococcus pneumoniae TIGR4

96.154

100

0.962
  comW Streptococcus mitis SK321

76.923

100

0.769
  comW Streptococcus mitis NCTC 12261

76.623

98.718

0.756

Multiple sequence alignment