Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   R8623_RS08405 Genome accession   NZ_AP026928
Coordinates   1644798..1645457 (+) Length   219 a.a.
NCBI ID   WP_000565005.1    Uniprot ID   A0A0B7LMM1
Organism   Streptococcus pneumoniae strain PZ900700406     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1639798..1650457
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8623_RS08380 (PC0401_16470) - 1640103..1640420 (-) 318 WP_024477881.1 PTS sugar transporter subunit IIB -
  R8623_RS08385 (PC0401_16480) - 1640435..1641331 (-) 897 WP_000825668.1 PEP phosphonomutase -
  R8623_RS08390 (PC0401_16490) - 1641334..1642596 (-) 1263 WP_000413336.1 PTS sugar transporter subunit IIC -
  R8623_RS08395 (PC0401_16500) - 1642876..1644054 (+) 1179 WP_024477882.1 ROK family transcriptional regulator -
  R8623_RS08400 (PC0401_16510) - 1644282..1644728 (-) 447 WP_000155425.1 GNAT family N-acetyltransferase -
  R8623_RS08405 (PC0401_16520) cclA/cilC 1644798..1645457 (+) 660 WP_000565005.1 A24 family peptidase Machinery gene
  R8623_RS08410 (PC0401_16530) - 1645509..1646660 (-) 1152 WP_024477883.1 XRE family transcriptional regulator -
  R8623_RS08415 (PC0401_16540) - 1646675..1647406 (-) 732 WP_000934016.1 hypothetical protein -
  R8623_RS08420 - 1647635..1647736 (+) 102 Protein_1666 prepilin peptidase -
  R8623_RS08425 (PC0401_16550) trpA 1647708..1648484 (-) 777 WP_317649568.1 tryptophan synthase subunit alpha -
  R8623_RS08430 (PC0401_16560) trpB 1648477..1649700 (-) 1224 WP_317649570.1 tryptophan synthase subunit beta -
  R8623_RS08435 (PC0401_16570) - 1649678..1650277 (-) 600 WP_317649571.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24846.03 Da        Isoelectric Point: 7.8950

>NTDB_id=98597 R8623_RS08405 WP_000565005.1 1644798..1645457(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700406]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSKVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=98597 R8623_RS08405 WP_000565005.1 1644798..1645457(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700406]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTAAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LMM1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

99.543

100

0.995
  cclA/cilC Streptococcus pneumoniae D39

99.543

100

0.995
  cclA/cilC Streptococcus pneumoniae R6

99.543

100

0.995
  cclA/cilC Streptococcus pneumoniae TIGR4

94.521

100

0.945
  cclA/cilC Streptococcus mitis SK321

92.237

100

0.922
  cclA/cilC Streptococcus mitis NCTC 12261

87.215

100

0.872

Multiple sequence alignment