Detailed information NTG0098569

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8623_RS02490
• Genome accession: NZ_AP026928
• Coordinates: 487615..488352 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain PZ900700406
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 482615..493352

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8623_RS02455	-	483591..483785 (-)	195	WP_001808905.1	hypothetical protein	-
R8623_RS02460 (PC0401_04790)	-	483947..484234 (-)	288	WP_000777753.1	hypothetical protein	-
R8623_RS02465 (PC0401_04800)	-	484244..484654 (-)	411	WP_001278301.1	HIT family protein	-
R8623_RS02470 (PC0401_04810)	pptA	484722..485453 (+)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
R8623_RS02475 (PC0401_04820)	-	485450..486499 (+)	1050	WP_000653771.1	ABC transporter permease	-
R8623_RS02480 (PC0401_04830)	-	486667..486996 (-)	330	WP_000132572.1	hypothetical protein	-
R8623_RS02485 (PC0401_04840)	-	487272..487610 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
R8623_RS02490 (PC0401_04850)	comE/blpR	487615..488352 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
R8623_RS02495 (PC0401_04860)	-	488366..489706 (+)	1341	WP_001017642.1	sensor histidine kinase	-
R8623_RS02500 (PC0401_04870)	blpC	489777..489905 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8623_RS02505 (PC0401_04880)	-	489962..491323 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
R8623_RS02510 (PC0401_04890)	comA/nlmT	491334..493010 (-)	1677	WP_215729172.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=98569 R8623_RS02490 WP_001219120.1 487615..488352(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700406]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=98569 R8623_RS02490 WP_001219120.1 487615..488352(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700406]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363