Detailed information NTG0098172

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8625_RS02430
• Genome accession: NZ_AP026923
• Coordinates: 476450..477187 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219126.1
• Uniprot ID: A7XHJ0
• Organism: Streptococcus pneumoniae strain PZ900700054
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 471450..482187

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8625_RS02395 (PC0054_04700)	-	472336..472620 (-)	285	WP_050150649.1	hypothetical protein	-
R8625_RS02400 (PC0054_04710)	-	472782..473069 (-)	288	WP_317649295.1	hypothetical protein	-
R8625_RS02405 (PC0054_04720)	-	473079..473489 (-)	411	WP_001278301.1	HIT family protein	-
R8625_RS02410 (PC0054_04730)	pptA	473557..474288 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
R8625_RS02415 (PC0054_04740)	-	474285..475334 (+)	1050	WP_000653752.1	ABC transporter permease	-
R8625_RS02420 (PC0054_04750)	-	475502..475831 (-)	330	WP_000132575.1	hypothetical protein	-
R8625_RS02425 (PC0054_04760)	-	476107..476445 (+)	339	WP_000682122.1	LytTR family DNA-binding domain-containing protein	-
R8625_RS02430 (PC0054_04770)	comE/blpR	476450..477187 (+)	738	WP_001219126.1	response regulator transcription factor	Regulator
R8625_RS02435 (PC0054_04780)	-	477200..478540 (+)	1341	WP_000275284.1	sensor histidine kinase	-
R8625_RS02440 (PC0054_04790)	-	478780..480126 (-)	1347	WP_001816270.1	IS1380-like element ISSpn5 family transposase	-
R8625_RS02445 (PC0054_04800)	blpC	480293..480448 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
R8625_RS02450 (PC0054_04810)	-	480505..481866 (-)	1362	WP_001069099.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.92 Da
• Isoelectric Point: 6.2357

>NTDB_id=98172 R8625_RS02430 WP_001219126.1 476450..477187(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700054]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=98172 R8625_RS02430 WP_001219126.1 476450..477187(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700054]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A7XHJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384