Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   R8566_RS09085 Genome accession   NZ_AP026920
Coordinates   1767414..1768073 (+) Length   219 a.a.
NCBI ID   WP_000565019.1    Uniprot ID   A0A0T9ICH6
Organism   Streptococcus pneumoniae strain PZ900700014     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1762414..1773073
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8566_RS09045 (PC0014_18140) mgaSpn 1762570..1764051 (-) 1482 WP_001205278.1 virulence factor transcriptional regulator MgaSpn -
  R8566_RS09050 (PC0014_18150) - 1764494..1764658 (+) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  R8566_RS09055 amaP 1764742..1765308 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  R8566_RS09060 (PC0014_18170) - 1765320..1765490 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  R8566_RS09065 (PC0014_18180) - 1765529..1766137 (+) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  R8566_RS09070 (PC0014_18190) - 1766168..1766371 (+) 204 WP_000109957.1 CsbD family protein -
  R8566_RS09075 (PC0014_18200) - 1766481..1766720 (-) 240 WP_001005784.1 transposase -
  R8566_RS09080 (PC0014_18210) - 1766898..1767344 (-) 447 WP_000155412.1 GNAT family N-acetyltransferase -
  R8566_RS09085 (PC0014_18220) cclA/cilC 1767414..1768073 (+) 660 WP_000565019.1 A24 family peptidase Machinery gene
  R8566_RS09090 (PC0014_18230) - 1768125..1769276 (-) 1152 WP_000481754.1 XRE family transcriptional regulator -
  R8566_RS09095 (PC0014_18240) - 1769291..1770022 (-) 732 WP_000934018.1 hypothetical protein -
  R8566_RS09100 - 1770248..1770352 (+) 105 Protein_1796 prepilin peptidase -
  R8566_RS09105 (PC0014_18250) trpA 1770324..1771100 (-) 777 WP_001127046.1 tryptophan synthase subunit alpha -
  R8566_RS09110 (PC0014_18260) trpB 1771093..1772316 (-) 1224 WP_000331257.1 tryptophan synthase subunit beta -
  R8566_RS09115 (PC0014_18270) - 1772294..1772893 (-) 600 WP_000169927.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24879.99 Da        Isoelectric Point: 7.6418

>NTDB_id=97963 R8566_RS09085 WP_000565019.1 1767414..1768073(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700014]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=97963 R8566_RS09085 WP_000565019.1 1767414..1768073(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700014]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTAGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATTCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0T9ICH6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

97.26

100

0.973
  cclA/cilC Streptococcus pneumoniae Rx1

96.347

100

0.963
  cclA/cilC Streptococcus pneumoniae D39

96.347

100

0.963
  cclA/cilC Streptococcus pneumoniae R6

96.347

100

0.963
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

86.301

100

0.863

Multiple sequence alignment