Detailed information NTG0097867

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: R8613_RS04735
• Genome accession: NZ_AP026919
• Coordinates: 909856..912096 (+)
• Length: 746 a.a.
• NCBI ID: WP_000942387.1
• Uniprot ID: A0AAX3HGB1
• Organism: Streptococcus pneumoniae strain PZ900700012
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 904856..917096

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8613_RS04705 (PC0012_09060)	-	905006..905974 (+)	969	WP_000658183.1	PhoH family protein	-
R8613_RS04710 (PC0012_09070)	-	906167..906667 (+)	501	WP_000566983.1	GNAT family N-acetyltransferase	-
R8613_RS04715 (PC0012_09080)	-	906670..906996 (+)	327	Protein_935	TfoX/Sxy family protein	-
R8613_RS04720	ald	907297..908408 (-)	1112	Protein_936	alanine dehydrogenase	-
R8613_RS04725 (PC0012_09120)	-	908585..909154 (+)	570	WP_000443744.1	GNAT family N-acetyltransferase	-
R8613_RS04730 (PC0012_09130)	comEA/celA/cilE	909222..909872 (+)	651	WP_000387331.1	ComEA family DNA-binding protein	Machinery gene
R8613_RS04735 (PC0012_09140)	comEC/celB	909856..912096 (+)	2241	WP_000942387.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
R8613_RS04740 (PC0012_09150)	-	912238..912462 (+)	225	WP_001813351.1	hypothetical protein	-
R8613_RS04745 (PC0012_09160)	-	912494..913081 (+)	588	WP_000945253.1	ATP-binding cassette domain-containing protein	-
R8613_RS04750 (PC0012_09170)	-	913085..914266 (+)	1182	WP_000655954.1	hypothetical protein	-
R8613_RS04755 (PC0012_09180)	infC	914573..915103 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
R8613_RS04760 (PC0012_09190)	rpmI	915136..915336 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
R8613_RS04765 (PC0012_09200)	rplT	915388..915747 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
R8613_RS04770 (PC0012_09210)	-	915805..916185 (+)	381	WP_000157154.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84545.20 Da
• Isoelectric Point: 9.7371

>NTDB_id=97867 R8613_RS04735 WP_000942387.1 909856..912096(+) (comEC/celB) [Streptococcus pneumoniae strain PZ900700012]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPLSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVVELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGWNSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=97867 R8613_RS04735 WP_000942387.1 909856..912096(+) (comEC/celB) [Streptococcus pneumoniae strain PZ900700012]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGTATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTTGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGACAAGTAGACCTCTGGTCTTTGGACAACCCAATGCATGGTTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGAAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAAATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCCCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGGTTTAAAGGTTGGAATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (30-177)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae Rx1	97.319	100	0.973
comEC/celB	Streptococcus pneumoniae D39	97.319	100	0.973
comEC/celB	Streptococcus pneumoniae R6	97.319	100	0.973
comEC/celB	Streptococcus pneumoniae TIGR4	97.319	100	0.973
comEC/celB	Streptococcus mitis NCTC 12261	92.483	99.866	0.924
comEC/celB	Streptococcus mitis SK321	92.225	100	0.922
comEC	Lactococcus lactis subsp. cremoris KW2	44.804	99.33	0.445