Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R8613_RS02695 Genome accession   NZ_AP026919
Coordinates   508516..509253 (+) Length   245 a.a.
NCBI ID   WP_001219121.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700012     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 503516..514253
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8613_RS02665 (PC0012_05080) - 504848..505135 (-) 288 WP_000777760.1 hypothetical protein -
  R8613_RS02670 (PC0012_05090) - 505145..505555 (-) 411 WP_050282188.1 HIT family protein -
  R8613_RS02675 (PC0012_05100) pptA 505623..506354 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  R8613_RS02680 (PC0012_05110) - 506351..507400 (+) 1050 WP_050154083.1 ABC transporter permease -
  R8613_RS02685 (PC0012_05120) - 507568..507897 (-) 330 WP_000132575.1 hypothetical protein -
  R8613_RS02690 (PC0012_05130) - 508173..508511 (+) 339 WP_000876675.1 LytTR family DNA-binding domain-containing protein -
  R8613_RS02695 (PC0012_05140) comE/blpR 508516..509253 (+) 738 WP_001219121.1 response regulator transcription factor Regulator
  R8613_RS02700 (PC0012_05150) - 509267..510607 (+) 1341 WP_001099893.1 sensor histidine kinase -
  R8613_RS02705 (PC0012_05160) blpC 510651..510806 (-) 156 WP_000358811.1 quorum-sensing system pheromone BlpC -
  R8613_RS02710 (PC0012_05170) - 510863..512224 (-) 1362 WP_001865175.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28740.91 Da        Isoelectric Point: 6.4140

>NTDB_id=97858 R8613_RS02695 WP_001219121.1 508516..509253(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700012]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=97858 R8613_RS02695 WP_001219121.1 508516..509253(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700012]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38

Multiple sequence alignment