Detailed information NTG0978476

Bioinformatically predicted

Overview

• Name: comYF
• Type: Machinery gene
• Locus tag: MGAS37642_RS00750
• Genome accession: NZ_CP151468
• Coordinates: 110950..111384 (+)
• Length: 144 a.a.
• NCBI ID: WP_010921800.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS37642
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 105950..116384

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS37642_RS00720 (MGAS37642_00292)	-	107619..107984 (+)	366	WP_002986560.1	DUF1033 family protein	-
MGAS37642_RS00725 (MGAS37642_00294)	comYA	108077..109015 (+)	939	WP_010921798.1	competence type IV pilus ATPase ComGA	Machinery gene
MGAS37642_RS00730 (MGAS37642_00296)	comYB	108951..109985 (+)	1035	WP_011054115.1	competence type IV pilus assembly protein ComGB	Machinery gene
MGAS37642_RS00735 (MGAS37642_00298)	comYC	109987..110313 (+)	327	WP_002986552.1	competence type IV pilus major pilin ComGC	Machinery gene
MGAS37642_RS00740 (MGAS37642_00300)	comGD	110288..110716 (+)	429	WP_002986548.1	competence type IV pilus minor pilin ComGD	-
MGAS37642_RS00745 (MGAS37642_00302)	comGE	110673..110957 (+)	285	WP_002987779.1	competence type IV pilus minor pilin ComGE	-
MGAS37642_RS00750 (MGAS37642_00304)	comYF	110950..111384 (+)	435	WP_010921800.1	competence type IV pilus minor pilin ComGF	Machinery gene
MGAS37642_RS00755 (MGAS37642_00306)	comGG	111368..111694 (+)	327	WP_010921801.1	competence type IV pilus minor pilin ComGG	-
MGAS37642_RS00760 (MGAS37642_00308)	comYH	111792..112745 (+)	954	WP_010921802.1	class I SAM-dependent methyltransferase	Machinery gene
MGAS37642_RS00765 (MGAS37642_00310)	-	112804..114000 (+)	1197	WP_010921803.1	acetate kinase	-
MGAS37642_RS00770	-	114187..114495 (+)	309	WP_010921804.1	hypothetical protein	-
MGAS37642_RS00775 (MGAS37642_00312)	proC	114578..115348 (-)	771	WP_010921805.1	pyrroline-5-carboxylate reductase	-

Sequence

Protein

• Length: 144 a.a.
• Molecular weight: 16654.28 Da
• Isoelectric Point: 10.2526

>NTDB_id=978476 MGAS37642_RS00750 WP_010921800.1 110950..111384(+) (comYF) [Streptococcus pyogenes strain MGAS37642]
MSKQLSNIKAFTLLEALIALLVISGSLLVYQGLTRTLLKHSHYLARHDQDNWLLFSHQLREELSGARFYKVADNKLYVEK
GKKVLAFGQFKSHDFRKSASNGKGYQPMLFGISRSHIHIEQSQICITLKWKSGLERTFYYAFQD

Nucleotide

• Length: 435 bp

>NTDB_id=978476 MGAS37642_RS00750 WP_010921800.1 110950..111384(+) (comYF) [Streptococcus pyogenes strain MGAS37642]
TTGAGTAAACAATTAAGTAACATAAAAGCTTTTACCCTTCTAGAGGCGTTAATAGCCTTACTCGTGATATCAGGGTCTTT
ATTGGTTTATCAAGGTTTGACCCGAACCCTCCTTAAACATAGCCATTATCTAGCCCGTCATGATCAAGATAATTGGCTCT
TATTTTCTCATCAATTGCGAGAGGAGTTAAGTGGAGCAAGGTTTTACAAAGTAGCTGATAATAAACTATACGTTGAAAAA
GGAAAGAAAGTACTAGCTTTTGGCCAATTTAAAAGTCATGATTTTCGAAAATCAGCTAGTAATGGAAAAGGGTATCAACC
CATGTTATTTGGAATATCACGTAGTCATATTCACATAGAGCAGTCACAGATTTGCATTACTTTAAAGTGGAAAAGTGGGT
TAGAAAGGACTTTTTATTATGCCTTTCAAGACTAA

Domains

Predicted by InterproScan.

• Putative Competence protein ComGF (ComGF) (41-135)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYF	Streptococcus mutans UA140	51.079	96.528	0.493
comYF	Streptococcus mutans UA159	50.36	96.528	0.486
comGF	Lactococcus lactis subsp. cremoris KW2	47.445	95.139	0.451
comGF/cglF	Streptococcus mitis NCTC 12261	44.03	93.056	0.41
comGF/cglF	Streptococcus pneumoniae Rx1	42.857	92.361	0.396
comGF/cglF	Streptococcus pneumoniae D39	42.857	92.361	0.396
comGF/cglF	Streptococcus pneumoniae R6	42.857	92.361	0.396
comGF/cglF	Streptococcus pneumoniae TIGR4	42.857	92.361	0.396
comGF/cglF	Streptococcus mitis SK321	42.105	92.361	0.389