Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   R8619_RS06245 Genome accession   NZ_AP026918
Coordinates   1226424..1227161 (-) Length   245 a.a.
NCBI ID   WP_000782680.1    Uniprot ID   A0A0B7L5A1
Organism   Streptococcus pneumoniae strain PZ900700009     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1221424..1232161
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8619_RS06225 (PC0009_12250) msrB 1222793..1223731 (-) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -
  R8619_RS06230 (PC0009_12260) - 1223798..1224040 (-) 243 WP_050213164.1 hypothetical protein -
  R8619_RS06235 (PC0009_12270) thrB 1224116..1224985 (-) 870 WP_000692438.1 homoserine kinase -
  R8619_RS06240 (PC0009_12280) - 1224987..1226273 (-) 1287 WP_000216382.1 homoserine dehydrogenase -
  R8619_RS06245 (PC0009_12290) mecA 1226424..1227161 (-) 738 WP_000782680.1 adaptor protein MecA Regulator
  R8619_RS06250 (PC0009_12300) - 1227361..1228395 (-) 1035 WP_000461502.1 hypothetical protein -
  R8619_RS06255 (PC0009_12310) - 1228424..1229857 (-) 1434 WP_000565082.1 O-antigen polysaccharide polymerase Wzy family protein -
  R8619_RS06260 (PC0009_12320) - 1229873..1230859 (-) 987 WP_000446980.1 glycosyltransferase family 2 protein -
  R8619_RS06265 (PC0009_12330) - 1230861..1231964 (-) 1104 WP_000225897.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28409.24 Da        Isoelectric Point: 4.0199

>NTDB_id=97797 R8619_RS06245 WP_000782680.1 1226424..1227161(-) (mecA) [Streptococcus pneumoniae strain PZ900700009]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVVFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=97797 R8619_RS06245 WP_000782680.1 1226424..1227161(-) (mecA) [Streptococcus pneumoniae strain PZ900700009]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAACTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGTTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7L5A1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482

Multiple sequence alignment