Detailed information NTG0097730

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: R8563_RS08450
• Genome accession: NZ_AP026917
• Coordinates: 1642690..1643349 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain PZ900700007
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1637690..1648349

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8563_RS08425 (PC0007_16580)	-	1637995..1638312 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
R8563_RS08430 (PC0007_16590)	-	1638327..1639223 (-)	897	WP_000825668.1	PEP phosphonomutase	-
R8563_RS08435 (PC0007_16600)	-	1639226..1640488 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
R8563_RS08440 (PC0007_16610)	-	1640768..1641946 (+)	1179	WP_000175879.1	ROK family transcriptional regulator	-
R8563_RS08445 (PC0007_16620)	-	1642174..1642620 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
R8563_RS08450 (PC0007_16630)	cclA/cilC	1642690..1643349 (+)	660	WP_000565017.1	A24 family peptidase	Machinery gene
R8563_RS08455 (PC0007_16640)	-	1643401..1644552 (-)	1152	WP_000481749.1	ImmA/IrrE family metallo-endopeptidase	-
R8563_RS08460 (PC0007_16650)	-	1644567..1645298 (-)	732	WP_000934017.1	hypothetical protein	-
R8563_RS08465	-	1645524..1645628 (+)	105	Protein_1672	prepilin peptidase	-
R8563_RS08470 (PC0007_16660)	trpA	1645600..1646376 (-)	777	WP_001127041.1	tryptophan synthase subunit alpha	-
R8563_RS08475 (PC0007_16670)	trpB	1646369..1647592 (-)	1224	WP_000331289.1	tryptophan synthase subunit beta	-
R8563_RS08480 (PC0007_16680)	-	1647570..1648169 (-)	600	WP_000169904.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=97730 R8563_RS08450 WP_000565017.1 1642690..1643349(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700007]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=97730 R8563_RS08450 WP_000565017.1 1642690..1643349(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700007]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGATCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858