Detailed information NTG0097577

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: R8775_RS08370
• Genome accession: NZ_AP026915
• Coordinates: 1618506..1619165 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565010.1
• Uniprot ID: A0A0B7M2C6
• Organism: Streptococcus pneumoniae strain PZ900700005
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1613506..1624165

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8775_RS08345 (PC0005_16460)	-	1613814..1614131 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
R8775_RS08350 (PC0005_16470)	-	1614146..1615042 (-)	897	WP_016398462.1	hypothetical protein	-
R8775_RS08355 (PC0005_16480)	-	1615045..1616304 (-)	1260	WP_317680910.1	PTS sugar transporter subunit IIC	-
R8775_RS08360 (PC0005_16490)	-	1616584..1617762 (+)	1179	WP_001866460.1	ROK family transcriptional regulator	-
R8775_RS08365 (PC0005_16500)	-	1618038..1618436 (-)	399	WP_050233566.1	GNAT family N-acetyltransferase	-
R8775_RS08370 (PC0005_16510)	cclA/cilC	1618506..1619165 (+)	660	WP_000565010.1	A24 family peptidase	Machinery gene
R8775_RS08375 (PC0005_16520)	-	1619217..1620368 (-)	1152	WP_000481756.1	XRE family transcriptional regulator	-
R8775_RS08380 (PC0005_16530)	-	1620383..1621114 (-)	732	Protein_1660	hypothetical protein	-
R8775_RS08385	-	1621340..1621444 (+)	105	Protein_1661	prepilin peptidase	-
R8775_RS08390 (PC0005_16550)	trpA	1621416..1622192 (-)	777	WP_317680911.1	tryptophan synthase subunit alpha	-
R8775_RS08395 (PC0005_16560)	trpB	1622185..1623408 (-)	1224	WP_000331288.1	tryptophan synthase subunit beta	-
R8775_RS08400 (PC0005_16570)	-	1623386..1623985 (-)	600	WP_050233567.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24845.99 Da
• Isoelectric Point: 7.5762

>NTDB_id=97577 R8775_RS08370 WP_000565010.1 1618506..1619165(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700005]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=97577 R8775_RS08370 WP_000565010.1 1618506..1619165(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700005]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGTAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M2C6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	100	100	1
cclA/cilC	Streptococcus pneumoniae D39	100	100	1
cclA/cilC	Streptococcus pneumoniae R6	100	100	1
cclA/cilC	Streptococcus pneumoniae TIGR4	94.977	100	0.95
cclA/cilC	Streptococcus mitis SK321	92.694	100	0.927
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877