Detailed information NTG0966201

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: NYE32_RS10375
• Genome accession: NZ_CP150201
• Coordinates: 2209214..2210449 (+)
• Length: 411 a.a.
• NCBI ID: WP_002892211.1
• Uniprot ID: J7SI15
• Organism: Streptococcus sp. FSL R7-0248
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2204214..2215449

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NYE32_RS10345 (NYE32_10345)	-	2204685..2207279 (+)	2595	WP_156685137.1	YfhO family protein	-
NYE32_RS10365 (NYE32_10365)	-	2207829..2208512 (-)	684	WP_002892206.1	YoaK family protein	-
NYE32_RS10370 (NYE32_10370)	rlmH	2208529..2209008 (-)	480	WP_037598563.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
NYE32_RS10375 (NYE32_10375)	htrA	2209214..2210449 (+)	1236	WP_002892211.1	trypsin-like peptidase domain-containing protein	Regulator
NYE32_RS10380 (NYE32_10380)	spo0J	2210515..2211282 (+)	768	WP_037599381.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 411 a.a.
• Molecular weight: 42959.14 Da
• Isoelectric Point: 4.6304

>NTDB_id=966201 NYE32_RS10375 WP_002892211.1 2209214..2210449(+) (htrA) [Streptococcus sp. FSL R7-0248]
MKKFNWKKIVAPIAMLVIGLLGGLLGAFILLTAAGVSFTNTTDTGVKTAKTVYNNTTDTTKAVKKVQNAVVSVINYQEGS
SSDSLNELYGRIFGGDDSSDSSQDKSKDSDGLQVAGEGSGVIYKKDGKEAYIVTNNHVVDGAKKLEIMLSDGSKITGELV
GKDTYSDLAVVKVSSDKIKTVAEFADSNSLTVGEKAIAIGSPLGTEYANSVTEGIVSSLSRTVTMQNDNGETVSTNAIQT
DAAINPGNSGGALVNIEGQVIGINSSKISSTSAVAGSAVEGMGFAIPSNDVVEIINQLEKDGKVTRPALGISMADLNSLS
SSATSKLDLPDEVKSGVVVGSVQKGMPADGKLQENDVITEIDGKEISSKTDIQTNLYSHSIGDTIKVTFYRGKEKKTEEL
KLTKSTEDLSD

Nucleotide

• Length: 1236 bp

>NTDB_id=966201 NYE32_RS10375 WP_002892211.1 2209214..2210449(+) (htrA) [Streptococcus sp. FSL R7-0248]
GTGAAAAAATTTAACTGGAAAAAAATAGTAGCGCCAATTGCAATGCTTGTTATTGGCTTACTAGGTGGTCTACTAGGTGC
CTTTATCCTATTAACAGCAGCAGGGGTATCTTTTACCAATACAACAGATACAGGTGTTAAAACAGCTAAGACCGTATACA
ACAATACAACAGATACAACTAAGGCCGTTAAGAAAGTACAAAATGCCGTTGTTTCTGTCATCAATTACCAAGAAGGCTCA
TCTTCAGATTCCCTAAATGAACTTTATGGTCGTATTTTTGGTGGAGATGATAGTTCTGATTCTAGCCAAGACAAATCAAA
AGATTCTGATGGATTGCAAGTCGCTGGTGAAGGTTCCGGTGTTATCTATAAAAAAGATGGGAAAGAGGCCTACATCGTAA
CCAACAACCACGTTGTTGATGGTGCTAAAAAACTTGAAATCATGCTTTCAGATGGATCAAAAATTACTGGTGAACTCGTT
GGTAAAGATACTTACTCTGACCTAGCAGTTGTCAAAGTTTCTTCAGATAAAATAAAAACCGTCGCAGAATTTGCAGATTC
AAACTCCCTCACAGTTGGTGAAAAGGCAATTGCTATCGGTAGCCCACTTGGTACCGAATACGCCAACTCAGTAACAGAGG
GAATCGTATCTAGCCTTAGCCGTACCGTAACTATGCAAAACGACAATGGTGAAACTGTCTCAACAAATGCTATCCAAACA
GATGCTGCCATTAACCCTGGTAACTCTGGTGGTGCCTTAGTCAATATTGAAGGACAAGTTATCGGTATTAACTCAAGTAA
GATTTCATCAACGTCAGCAGTCGCTGGTAGTGCCGTTGAAGGTATGGGATTCGCCATTCCATCAAACGATGTTGTCGAAA
TCATTAATCAATTGGAAAAAGACGGTAAAGTTACACGCCCAGCCCTAGGAATCTCAATGGCCGATCTTAATAGCCTTTCT
AGCAGTGCAACTTCTAAATTAGATTTACCAGATGAAGTTAAATCTGGAGTTGTTGTCGGTAGCGTTCAAAAAGGTATGCC
AGCTGACGGTAAACTTCAAGAAAATGATGTTATTACTGAAATTGACGGTAAGGAAATCAGCTCAAAAACTGATATTCAAA
CCAATCTTTACAGCCATAGTATCGGAGATACAATCAAGGTAACCTTCTATCGTGGTAAAGAGAAGAAAACTGAAGAACTT
AAATTAACAAAATCTACAGAAGACTTATCTGACTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (118-263)

• Peptidase family M50 (Peptidase_M50) (4-406)

• PDZ domain (PDZ_2) (307-402)

3D structure

• AlphaFold DB: J7SI15

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.787	98.054	0.606
htrA	Streptococcus gordonii str. Challis substr. CH1	57.524	100	0.577
htrA	Streptococcus mitis NCTC 12261	54.768	99.513	0.545
htrA	Streptococcus pneumoniae TIGR4	54.523	99.513	0.543
htrA	Streptococcus pneumoniae D39	54.523	99.513	0.543
htrA	Streptococcus pneumoniae Rx1	54.523	99.513	0.543
htrA	Streptococcus pneumoniae R6	54.523	99.513	0.543