Detailed information NTG0095248

Bioinformatically predicted

Overview

• Name: comC/comC2
• Type: Regulator
• Locus tag: QML87_RS10325
• Genome accession: NZ_AP025936
• Coordinates: 2029836..2029961 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799686.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain PZ900700617
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Genomic Context

Location: 2024836..2034961

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QML87_RS10295	-	2025228..2026839 (-)	1612	Protein_2000	YhgE/Pip domain-containing protein	-
QML87_RS10300 (PC0607_20020)	-	2026967..2027509 (+)	543	WP_001158263.1	TetR/AcrR family transcriptional regulator	-
QML87_RS10315 (PC0607_20040)	comE	2027752..2028504 (-)	753	Protein_2002	competence system response regulator transcription factor ComE	-
QML87_RS10320	comD	2028501..2029815 (-)	1315	Protein_2003	competence system sensor histidine kinase ComD	-
QML87_RS10325	comC/comC2	2029836..2029961 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
QML87_RS10335 (PC0607_20070)	rlmH	2030243..2030722 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
QML87_RS10340 (PC0607_20080)	htrA	2030905..2032086 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
QML87_RS10345 (PC0607_20090)	spo0J	2032144..2032902 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4907.00 Da
• Isoelectric Point: 11.0006

>NTDB_id=95248 QML87_RS10325 WP_000799686.1 2029836..2029961(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700617]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide

• Length: 126 bp

>NTDB_id=95248 QML87_RS10325 WP_000799686.1 2029836..2029961(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700617]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-29)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC2	Streptococcus pneumoniae A66	100	100	1
comC/comC2	Streptococcus pneumoniae TIGR4	100	100	1
comC/comC1	Streptococcus pneumoniae R6	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae G54	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae D39	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae Rx1	80.488	100	0.805
comC	Streptococcus mitis SK321	75.61	100	0.756
comC	Streptococcus mitis NCTC 12261	57.5	97.561	0.561