Detailed information NTG0093742

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLID5_RS08180
• Genome accession: NZ_AP025701
• Coordinates: 1717348..1718040 (-)
• Length: 230 a.a.
• NCBI ID: WP_003130756.1
• Uniprot ID: S6EZK2
• Organism: Lactococcus lactis strain ID-5
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1712348..1723040

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLID5_RS08165 (LLID5_16140)	-	1713967..1714308 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
LLID5_RS08170 (LLID5_16150)	-	1714440..1715681 (-)	1242	WP_251918412.1	ammonium transporter	-
LLID5_RS08175 (LLID5_16160)	covS	1715864..1717339 (-)	1476	WP_251918414.1	HAMP domain-containing histidine kinase	Regulator
LLID5_RS08180 (LLID5_16170)	covR	1717348..1718040 (-)	693	WP_003130756.1	response regulator transcription factor	Regulator
LLID5_RS08185 (LLID5_16180)	-	1718196..1718726 (-)	531	WP_058212571.1	DUF177 domain-containing protein	-
LLID5_RS08190 (LLID5_16190)	-	1718857..1719102 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
LLID5_RS08195 (LLID5_16200)	-	1719258..1719722 (-)	465	WP_251918416.1	hypothetical protein	-
LLID5_RS08200 (LLID5_16210)	-	1719804..1720166 (-)	363	WP_251918418.1	TIGR02328 family protein	-
LLID5_RS12070	-	1720515..1720646 (-)	132	WP_286010145.1	hypothetical protein	-
LLID5_RS08205 (LLID5_16220)	-	1720650..1721105 (-)	456	WP_251918420.1	CHAP domain-containing protein	-
LLID5_RS08210 (LLID5_16230)	-	1721167..1722003 (-)	837	WP_023164354.1	metallophosphoesterase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26684.36 Da
• Isoelectric Point: 5.1273

>NTDB_id=93742 LLID5_RS08180 WP_003130756.1 1717348..1718040(-) (covR) [Lactococcus lactis strain ID-5]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=93742 LLID5_RS08180 WP_003130756.1 1717348..1718040(-) (covR) [Lactococcus lactis strain ID-5]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACAGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: S6EZK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361