Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   VKP40_RS07660 Genome accession   NZ_CP142355
Coordinates   1519698..1520384 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain A946     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1514698..1525384
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP40_RS07640 (VKP40_07640) - 1514997..1516172 (-) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  VKP40_RS07645 (VKP40_07645) nrdR 1516156..1516650 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  VKP40_RS07650 (VKP40_07650) - 1516822..1517955 (-) 1134 WP_000564846.1 ISAs1-like element IS1548 family transposase -
  VKP40_RS07655 (VKP40_07655) covS 1518190..1519692 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  VKP40_RS07660 (VKP40_07660) covR 1519698..1520384 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  VKP40_RS07665 (VKP40_07665) - 1520651..1521184 (-) 534 WP_014635288.1 YceD family protein -
  VKP40_RS07670 (VKP40_07670) htpX 1521418..1522314 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  VKP40_RS07675 (VKP40_07675) - 1522361..1522918 (-) 558 WP_002985956.1 LemA family protein -
  VKP40_RS07680 (VKP40_07680) rsmG 1523068..1523781 (+) 714 WP_014407313.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  VKP40_RS07685 (VKP40_07685) ktrB 1523865..1525241 (+) 1377 WP_326676173.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=925288 VKP40_RS07660 WP_002991052.1 1519698..1520384(-) (covR) [Streptococcus pyogenes strain A946]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=925288 VKP40_RS07660 WP_002991052.1 1519698..1520384(-) (covR) [Streptococcus pyogenes strain A946]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGGTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACATATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425