Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   VKP53_RS07595 Genome accession   NZ_CP142354
Coordinates   1530016..1530702 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 6745-99     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1525016..1535702
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP53_RS07575 (VKP53_07575) dnaI 1525737..1526639 (-) 903 WP_326674766.1 primosomal protein DnaI -
  VKP53_RS07580 (VKP53_07580) - 1526640..1527815 (-) 1176 WP_032467298.1 replication initiation and membrane attachment family protein -
  VKP53_RS07585 (VKP53_07585) nrdR 1527799..1528293 (-) 495 WP_115230680.1 transcriptional regulator NrdR -
  VKP53_RS07590 (VKP53_07590) covS 1528508..1530010 (-) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  VKP53_RS07595 (VKP53_07595) covR 1530016..1530702 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  VKP53_RS07600 (VKP53_07600) - 1530969..1531502 (-) 534 WP_194118352.1 YceD family protein -
  VKP53_RS07605 (VKP53_07605) htpX 1531736..1532632 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  VKP53_RS07610 (VKP53_07610) - 1532679..1533236 (-) 558 WP_002985956.1 LemA family protein -
  VKP53_RS07615 (VKP53_07615) rsmG 1533386..1534099 (+) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  VKP53_RS07620 (VKP53_07620) ktrB 1534184..1535560 (+) 1377 WP_168391525.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=925234 VKP53_RS07595 WP_002991052.1 1530016..1530702(-) (covR) [Streptococcus pyogenes strain 6745-99]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=925234 VKP53_RS07595 WP_002991052.1 1530016..1530702(-) (covR) [Streptococcus pyogenes strain 6745-99]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCTGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425