Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   VKP55_RS01745 Genome accession   NZ_CP142351
Coordinates   322412..323098 (+) Length   228 a.a.
NCBI ID   WP_326674342.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain SS1366     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 317412..328098
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP55_RS01720 (VKP55_01720) ktrB 317554..318930 (-) 1377 WP_033887684.1 potassium uptake transporter channel subunit KtrB -
  VKP55_RS01725 (VKP55_01725) rsmG 319015..319728 (-) 714 WP_014407313.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  VKP55_RS01730 (VKP55_01730) - 319878..320435 (+) 558 WP_002985956.1 LemA family protein -
  VKP55_RS01735 (VKP55_01735) htpX 320482..321378 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  VKP55_RS01740 (VKP55_01740) - 321612..322145 (+) 534 WP_032464180.1 YceD family protein -
  VKP55_RS01745 (VKP55_01745) covR 322412..323098 (+) 687 WP_326674342.1 two-component system response regulator CovR Regulator
  VKP55_RS01750 (VKP55_01750) covS 323104..324606 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  VKP55_RS01755 (VKP55_01755) nrdR 324821..325315 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  VKP55_RS01760 (VKP55_01760) - 325299..326474 (+) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  VKP55_RS01765 (VKP55_01765) dnaI 326475..327377 (+) 903 WP_002985938.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26590.64 Da        Isoelectric Point: 4.6586

>NTDB_id=925041 VKP55_RS01745 WP_326674342.1 322412..323098(+) (covR) [Streptococcus pyogenes strain SS1366]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEANGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=925041 VKP55_RS01745 WP_326674342.1 322412..323098(+) (covR) [Streptococcus pyogenes strain SS1366]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGGTA
TGAAGTCATTGTTGAGGCCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425