Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   VKP35_RS08010 Genome accession   NZ_CP142349
Coordinates   1545720..1546406 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 11RS100     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1540720..1551406
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP35_RS07990 (VKP35_07990) dnaI 1541441..1542343 (-) 903 WP_002985938.1 primosomal protein DnaI -
  VKP35_RS07995 (VKP35_07995) - 1542344..1543519 (-) 1176 WP_032467298.1 replication initiation and membrane attachment family protein -
  VKP35_RS08000 (VKP35_08000) nrdR 1543503..1543997 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  VKP35_RS08005 (VKP35_08005) covS 1544212..1545714 (-) 1503 WP_326622688.1 two-component system sensor histidine kinase CovS -
  VKP35_RS08010 (VKP35_08010) covR 1545720..1546406 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  VKP35_RS08015 (VKP35_08015) - 1546673..1547206 (-) 534 WP_011054200.1 YceD family protein -
  VKP35_RS08020 (VKP35_08020) htpX 1547440..1548336 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  VKP35_RS08025 (VKP35_08025) - 1548383..1548940 (-) 558 WP_002985956.1 LemA family protein -
  VKP35_RS08030 (VKP35_08030) rsmG 1549091..1549804 (+) 714 WP_111685178.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  VKP35_RS08035 (VKP35_08035) ktrB 1549889..1551265 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=924958 VKP35_RS08010 WP_002991052.1 1545720..1546406(-) (covR) [Streptococcus pyogenes strain 11RS100]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=924958 VKP35_RS08010 WP_002991052.1 1545720..1546406(-) (covR) [Streptococcus pyogenes strain 11RS100]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GACTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425