Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   AB3422_RS12120 Genome accession   NZ_CP162463
Coordinates   2486896..2487519 (-) Length   207 a.a.
NCBI ID   WP_001045133.1    Uniprot ID   A0A0H2XHP5
Organism   Staphylococcus aureus strain TUM20888     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2481896..2492519
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AB3422_RS12095 (AB3422_12095) - 2482392..2483588 (-) 1197 WP_000238227.1 exonuclease SbcCD subunit D -
  AB3422_RS12100 (AB3422_12100) - 2483879..2483977 (-) 99 WP_001791795.1 hypothetical protein -
  AB3422_RS12105 (AB3422_12105) - 2484360..2484704 (-) 345 WP_000290301.1 YlbF/YmcA family competence regulator -
  AB3422_RS12110 (AB3422_12110) - 2484773..2485897 (-) 1125 WP_000992527.1 DUF445 domain-containing protein -
  AB3422_RS12115 (AB3422_12115) - 2486076..2486540 (-) 465 WP_000375864.1 helix-turn-helix transcriptional regulator -
  AB3422_RS12120 (AB3422_12120) vraR 2486896..2487519 (-) 624 WP_001045133.1 response regulator transcription factor Regulator
  AB3422_RS12125 (AB3422_12125) - 2487541..2488653 (-) 1113 WP_000437967.1 GAF domain-containing sensor histidine kinase -
  AB3422_RS12130 (AB3422_12130) - 2488816..2489637 (+) 822 WP_000669376.1 RluA family pseudouridine synthase -
  AB3422_RS12135 (AB3422_12135) - 2490385..2490858 (-) 474 WP_078096690.1 IS30 family transposase -
  AB3422_RS12140 (AB3422_12140) - 2490839..2491369 (-) 531 WP_108957673.1 helix-turn-helix domain-containing protein -
  AB3422_RS12145 (AB3422_12145) - 2491481..2491843 (-) 363 WP_031904066.1 cystatin-like fold lipoprotein -
  AB3422_RS12150 (AB3422_12150) - 2491891..2492484 (-) 594 WP_031904065.1 hypothetical protein -

Sequence

Protein


Download         Length: 207 a.a.        Molecular weight: 23895.56 Da        Isoelectric Point: 5.5730

>NTDB_id=923154 AB3422_RS12120 WP_001045133.1 2486896..2487519(-) (vraR) [Staphylococcus aureus strain TUM20888]
MNKVILVDDHYIVRQGLRFLLSTIENIEVLQDFADGETFLEYLKEHEHPDIVLLDLVMPGMNGIEITEYIKAHYPDIKVL
VLTSYVDDEHVISAINKGADGYEMKDVEPQQLIETIRRVMNGEKMIHPKAQDVFETVSQKPHYTNKLSKREIEVLREMVK
GKTNKEIAETLFVSEKTIKTHVSHIFSKLQVSDRTQAAIYAMENKLI

Nucleotide


Download         Length: 624 bp        

>NTDB_id=923154 AB3422_RS12120 WP_001045133.1 2486896..2487519(-) (vraR) [Staphylococcus aureus strain TUM20888]
ATGAACAAAGTAATATTAGTAGATGACCATTATATTGTGCGACAAGGATTGCGATTTTTATTATCCACGATTGAAAACAT
AGAAGTTTTACAAGACTTTGCAGATGGAGAAACATTTTTAGAATATTTAAAAGAGCATGAGCACCCTGATATTGTGCTAT
TAGATTTAGTGATGCCTGGCATGAATGGTATTGAAATTACGGAATATATTAAGGCACATTATCCGGATATTAAAGTTTTG
GTATTAACAAGTTATGTTGATGATGAACATGTAATTTCAGCAATCAATAAAGGTGCTGATGGTTATGAAATGAAAGACGT
TGAGCCTCAGCAATTAATTGAAACTATTAGACGAGTTATGAACGGTGAAAAAATGATACATCCTAAGGCACAAGATGTAT
TCGAAACAGTTAGCCAAAAACCACACTACACGAATAAGTTGTCAAAGAGAGAAATTGAAGTGTTACGTGAAATGGTTAAA
GGTAAAACAAATAAAGAGATTGCAGAAACTTTATTTGTATCTGAAAAAACAATTAAAACACATGTCAGTCATATATTTAG
TAAATTACAAGTTAGCGATCGTACACAAGCAGCAATTTATGCAATGGAAAATAAGTTGATTTAG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-116)

Bacterial regulatory proteins, luxR family (GerE)

(146-201)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2XHP5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

40.58

100

0.406
  degU Bacillus subtilis subsp. subtilis str. 168

35.135

100

0.377
  letA Legionella pneumophila str. Paris

35.714

100

0.362
  letA Legionella pneumophila strain ERS1305867

35.714

100

0.362