Detailed information NTG0920989

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: VOI49_RS00370
• Genome accession: NZ_CP142018
• Coordinates: 57197..58108 (+)
• Length: 303 a.a.
• NCBI ID: WP_115246948.1
• Uniprot ID: A0A380K137
• Organism: Streptococcus dysgalactiae strain lu24
• Function: activate transcription of comX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	58165..59253	57197..58108	flank	57

Gene organization within MGE regions

Location: 57197..59253

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VOI49_RS00370	comR	57197..58108 (+)	912	WP_115246948.1	helix-turn-helix domain-containing protein	Regulator

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35952.51 Da
• Isoelectric Point: 4.6780

>NTDB_id=920989 VOI49_RS00370 WP_115246948.1 57197..58108(+) (comR) [Streptococcus dysgalactiae strain lu24]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDGKLQVRESQFDEIFENYYDQLPEEERIAIDIIQAKFEVYQTGDINFGFNILKEFLPQLKKRTVYNLNE
LLLIDLYLIILVVSNFTNDLFDEEFYKEITERILEQHQYLLLEDLFLLNNILLSCADTSIRLKMFERLKDTLQLSHFIMS
TIQDFQRMPMYCMYEWKLSIFYLKDIKRAETYFSQSLTFTQMTNDSYLAQKLQKEWDKDIHPS

Nucleotide

• Length: 912 bp

>NTDB_id=920989 VOI49_RS00370 WP_115246948.1 57197..58108(+) (comR) [Streptococcus dysgalactiae strain lu24]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGACTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTATGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCAAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATGGGAAATTGCAAGTCCGAGAGTCTCAGTTTGATGAGATATTCGA
AAACTATTATGATCAATTGCCCGAGGAGGAAAGAATAGCGATTGATATTATCCAGGCAAAATTTGAAGTTTATCAGACAG
GTGATATTAATTTTGGTTTTAATATTTTAAAAGAATTTCTACCACAACTAAAAAAGAGAACGGTTTATAACTTAAATGAA
TTATTATTAATTGATTTATATTTAATTATTTTAGTTGTTTCTAACTTCACAAATGACCTATTTGATGAGGAATTTTATAA
AGAAATAACGGAGCGAATCTTAGAACAGCATCAATACCTGTTGTTAGAAGATTTATTTCTATTAAATAATATTCTTTTGT
CTTGCGCAGATACTTCTATTCGTTTAAAAATGTTTGAACGACTAAAGGATACGTTACAACTCAGCCATTTTATTATGTCA
ACCATTCAAGATTTTCAACGAATGCCCATGTATTGCATGTATGAATGGAAATTATCTATCTTTTATTTAAAAGATATTAA
ACGAGCAGAAACTTATTTTAGTCAATCTCTCACGTTTACTCAAATGACTAATGATAGTTATTTGGCACAAAAGCTTCAAA
AAGAATGGGATAAGGATATTCATCCATCTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

3D structure

• AlphaFold DB: A0A380K137

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	83.056	99.34	0.825
comR	Streptococcus pyogenes MGAS8232	55.298	99.67	0.551
comR	Streptococcus mutans UA159	45.819	98.68	0.452
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.575	96.37	0.449