Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   U0450_RS07610 Genome accession   NZ_CP139863
Coordinates   1484031..1484690 (-) Length   219 a.a.
NCBI ID   WP_000565010.1    Uniprot ID   A0A0B7M2C6
Organism   Streptococcus pneumoniae strain 15P2112     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1466460..1493727 1484031..1484690 within 0


Gene organization within MGE regions


Location: 1466460..1493727
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0450_RS07515 - 1466460..1466756 (+) 297 WP_000239022.1 hypothetical protein -
  U0450_RS07520 - 1467004..1467318 (+) 315 Protein_1436 GDP-mannose 4,6-dehydratase -
  U0450_RS07525 - 1467482..1468141 (+) 660 WP_127245085.1 DUF1868 domain-containing protein -
  U0450_RS07530 - 1468166..1469233 (+) 1068 WP_000738354.1 extracellular solute-binding protein -
  U0450_RS07535 - 1469336..1470346 (+) 1011 WP_000589142.1 ABC transporter ATP-binding protein -
  U0450_RS07540 - 1470358..1472049 (+) 1692 WP_001216185.1 iron ABC transporter permease -
  U0450_RS07545 - 1472052..1472762 (+) 711 WP_000127552.1 MgtC/SapB family protein -
  U0450_RS07550 - 1472858..1473226 (+) 369 WP_127245083.1 hypothetical protein -
  U0450_RS07555 - 1473334..1474335 (+) 1002 WP_000789949.1 LacI family DNA-binding transcriptional regulator -
  U0450_RS07560 trpE 1475521..1476882 (+) 1362 WP_050233568.1 anthranilate synthase component I -
  U0450_RS07565 - 1476879..1477445 (+) 567 WP_000601926.1 aminodeoxychorismate/anthranilate synthase component II -
  U0450_RS07570 trpD 1477456..1478460 (+) 1005 WP_000658684.1 anthranilate phosphoribosyltransferase -
  U0450_RS07575 trpC 1478457..1479224 (+) 768 WP_000076548.1 indole-3-glycerol phosphate synthase TrpC -
  U0450_RS07580 - 1479211..1479810 (+) 600 WP_050233567.1 phosphoribosylanthranilate isomerase -
  U0450_RS07585 trpB 1479788..1481011 (+) 1224 WP_000331288.1 tryptophan synthase subunit beta -
  U0450_RS07590 trpA 1481004..1481780 (+) 777 WP_001127010.1 tryptophan synthase subunit alpha -
  U0450_RS07595 - 1481752..1481856 (-) 105 Protein_1451 prepilin peptidase -
  U0450_RS07600 - 1482082..1482813 (+) 732 Protein_1452 hypothetical protein -
  U0450_RS07605 - 1482828..1483979 (+) 1152 WP_000481756.1 XRE family transcriptional regulator -
  U0450_RS07610 cclA/cilC 1484031..1484690 (-) 660 WP_000565010.1 A24 family peptidase Machinery gene
  U0450_RS07615 - 1484760..1485158 (+) 399 WP_127245082.1 N-acetyltransferase -
  U0450_RS07620 - 1485434..1486612 (-) 1179 WP_001866460.1 ROK family transcriptional regulator -
  U0450_RS07625 - 1486892..1488154 (+) 1263 WP_127245081.1 PTS sugar transporter subunit IIC -
  U0450_RS07630 - 1488157..1489053 (+) 897 WP_000825669.1 PEP phosphonomutase -
  U0450_RS07635 - 1489068..1489385 (+) 318 WP_001151646.1 PTS sugar transporter subunit IIB -
  U0450_RS07640 - 1489402..1489719 (+) 318 WP_001005886.1 PTS lactose/cellobiose transporter subunit IIA -
  U0450_RS07645 - 1489729..1491084 (+) 1356 WP_001094996.1 PTS sugar transporter subunit IIC -
  U0450_RS07650 - 1491407..1492882 (+) 1476 WP_000250870.1 arylsulfatase -
  U0450_RS07655 - 1492879..1493727 (+) 849 WP_000782429.1 formylglycine-generating enzyme family protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24845.99 Da        Isoelectric Point: 7.5762

>NTDB_id=911593 U0450_RS07610 WP_000565010.1 1484031..1484690(-) (cclA/cilC) [Streptococcus pneumoniae strain 15P2112]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=911593 U0450_RS07610 WP_000565010.1 1484031..1484690(-) (cclA/cilC) [Streptococcus pneumoniae strain 15P2112]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGTAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M2C6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

100

100

1
  cclA/cilC Streptococcus pneumoniae D39

100

100

1
  cclA/cilC Streptococcus pneumoniae R6

100

100

1
  cclA/cilC Streptococcus pneumoniae TIGR4

94.977

100

0.95
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

87.671

100

0.877