Detailed information
Bioinformatically predicted
Overview
| Name | cclA/cilC | Type | Machinery gene |
| Locus tag | U0449_RS07505 | Genome accession | NZ_CP139862 |
| Coordinates | 1460003..1460662 (-) | Length | 219 a.a. |
| NCBI ID | WP_050168228.1 | Uniprot ID | A0A4J2EJU5 |
| Organism | Streptococcus pneumoniae strain 05H0020-2 | ||
| Function | processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
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Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Genomic island | 1442489..1476602 | 1460003..1460662 | within | 0 |
Gene organization within MGE regions
Location: 1442489..1476602
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| U0449_RS07405 | - | 1442489..1442785 (+) | 297 | WP_000239024.1 | hypothetical protein | - |
| U0449_RS07410 | - | 1443021..1443335 (+) | 315 | Protein_1416 | GDP-mannose 4,6-dehydratase | - |
| U0449_RS07415 | - | 1443499..1444158 (+) | 660 | WP_042516304.1 | DUF1868 domain-containing protein | - |
| U0449_RS07420 | - | 1444183..1445250 (+) | 1068 | WP_000738360.1 | extracellular solute-binding protein | - |
| U0449_RS07425 | - | 1445353..1446363 (+) | 1011 | WP_000589142.1 | ABC transporter ATP-binding protein | - |
| U0449_RS07430 | - | 1446375..1448066 (+) | 1692 | WP_001216179.1 | iron ABC transporter permease | - |
| U0449_RS07435 | - | 1448069..1448779 (+) | 711 | WP_000127552.1 | MgtC/SapB family protein | - |
| U0449_RS07440 | - | 1448875..1449243 (+) | 369 | WP_000656286.1 | hypothetical protein | - |
| U0449_RS07445 | - | 1449351..1450352 (+) | 1002 | WP_000789949.1 | LacI family DNA-binding transcriptional regulator | - |
| U0449_RS07450 | - | 1450960..1451121 (+) | 162 | WP_000692937.1 | hypothetical protein | - |
| U0449_RS07455 | trpE | 1451493..1452854 (+) | 1362 | WP_000439625.1 | anthranilate synthase component I | - |
| U0449_RS07460 | - | 1452851..1453417 (+) | 567 | WP_000601925.1 | aminodeoxychorismate/anthranilate synthase component II | - |
| U0449_RS07465 | trpD | 1453428..1454432 (+) | 1005 | WP_000658716.1 | anthranilate phosphoribosyltransferase | - |
| U0449_RS07470 | trpC | 1454429..1455196 (+) | 768 | WP_000076551.1 | indole-3-glycerol phosphate synthase TrpC | - |
| U0449_RS07475 | - | 1455183..1455782 (+) | 600 | WP_000169888.1 | phosphoribosylanthranilate isomerase | - |
| U0449_RS07480 | trpB | 1455760..1456983 (+) | 1224 | WP_000331298.1 | tryptophan synthase subunit beta | - |
| U0449_RS07485 | trpA | 1456976..1457752 (+) | 777 | WP_001126993.1 | tryptophan synthase subunit alpha | - |
| U0449_RS07490 | - | 1457724..1457873 (-) | 150 | Protein_1432 | prepilin peptidase | - |
| U0449_RS07495 | - | 1458054..1458785 (+) | 732 | WP_000934017.1 | hypothetical protein | - |
| U0449_RS07500 | - | 1458800..1459951 (+) | 1152 | WP_050218970.1 | XRE family transcriptional regulator | - |
| U0449_RS07505 | cclA/cilC | 1460003..1460662 (-) | 660 | WP_050168228.1 | A24 family peptidase | Machinery gene |
| U0449_RS07510 | - | 1460732..1461130 (+) | 399 | WP_050102521.1 | GNAT family N-acetyltransferase | - |
| U0449_RS07515 | - | 1461406..1462584 (-) | 1179 | WP_000175876.1 | ROK family transcriptional regulator | - |
| U0449_RS07520 | - | 1462864..1464126 (+) | 1263 | WP_050218971.1 | PTS sugar transporter subunit IIC | - |
| U0449_RS07525 | - | 1464129..1465025 (+) | 897 | WP_000825669.1 | PEP phosphonomutase | - |
| U0449_RS07530 | - | 1465040..1465357 (+) | 318 | WP_001151646.1 | PTS sugar transporter subunit IIB | - |
| U0449_RS07535 | - | 1465374..1465691 (+) | 318 | WP_001005881.1 | PTS lactose/cellobiose transporter subunit IIA | - |
| U0449_RS07540 | - | 1465701..1467056 (+) | 1356 | WP_044791091.1 | PTS sugar transporter subunit IIC | - |
| U0449_RS07545 | - | 1467379..1468854 (+) | 1476 | WP_050218972.1 | arylsulfatase | - |
| U0449_RS07550 | - | 1468862..1469524 (+) | 663 | Protein_1444 | SUMF1/EgtB/PvdO family nonheme iron enzyme | - |
| U0449_RS07555 | - | 1469539..1470309 (+) | 771 | WP_000229339.1 | sulfite exporter TauE/SafE family protein | - |
| U0449_RS07560 | - | 1470587..1470832 (-) | 246 | WP_001867128.1 | IS30 family transposase | - |
| U0449_RS07565 | - | 1471111..1471350 (+) | 240 | WP_001005784.1 | transposase | - |
| U0449_RS07570 | - | 1471445..1471648 (-) | 204 | WP_000109957.1 | CsbD family protein | - |
| U0449_RS07575 | - | 1471679..1472287 (-) | 609 | WP_050218973.1 | Asp23/Gls24 family envelope stress response protein | - |
| U0449_RS07580 | - | 1472326..1472496 (-) | 171 | WP_000455066.1 | DUF2273 domain-containing protein | - |
| U0449_RS07585 | amaP | 1472508..1473074 (-) | 567 | WP_000030209.1 | alkaline shock response membrane anchor protein AmaP | - |
| U0449_RS07590 | - | 1473158..1473380 (-) | 223 | Protein_1452 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
| U0449_RS07595 | mgaSpn | 1473764..1475245 (+) | 1482 | WP_001205276.1 | virulence factor transcriptional regulator MgaSpn | - |
| U0449_RS07600 | - | 1475607..1476602 (+) | 996 | WP_000230210.1 | LacI family DNA-binding transcriptional regulator | - |
Sequence
Protein
Download Length: 219 a.a. Molecular weight: 24860.02 Da Isoelectric Point: 7.5762
>NTDB_id=911517 U0449_RS07505 WP_050168228.1 1460003..1460662(-) (cclA/cilC) [Streptococcus pneumoniae strain 05H0020-2]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACLIIFGKLLLV
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACLIIFGKLLLV
Nucleotide
Download Length: 660 bp
>NTDB_id=911517 U0449_RS07505 WP_050168228.1 1460003..1460662(-) (cclA/cilC) [Streptococcus pneumoniae strain 05H0020-2]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| cclA/cilC | Streptococcus pneumoniae Rx1 |
99.543 |
100 |
0.995 |
| cclA/cilC | Streptococcus pneumoniae D39 |
99.543 |
100 |
0.995 |
| cclA/cilC | Streptococcus pneumoniae R6 |
99.543 |
100 |
0.995 |
| cclA/cilC | Streptococcus pneumoniae TIGR4 |
95.434 |
100 |
0.954 |
| cclA/cilC | Streptococcus mitis SK321 |
92.237 |
100 |
0.922 |
| cclA/cilC | Streptococcus mitis NCTC 12261 |
87.215 |
100 |
0.872 |