Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   U0447_RS03140 Genome accession   NZ_CP139861
Coordinates   608461..609120 (+) Length   219 a.a.
NCBI ID   WP_000565023.1    Uniprot ID   A0A0I8D2P0
Organism   Streptococcus pneumoniae strain 16H2017-2     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 599424..628760 608461..609120 within 0


Gene organization within MGE regions


Location: 599424..628760
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0447_RS03095 - 599424..600272 (-) 849 WP_000782429.1 formylglycine-generating enzyme family protein -
  U0447_RS03100 - 600269..601744 (-) 1476 WP_000250870.1 arylsulfatase -
  U0447_RS03105 - 602067..603422 (-) 1356 WP_001094994.1 PTS sugar transporter subunit IIC -
  U0447_RS03110 - 603432..603749 (-) 318 WP_050232557.1 PTS lactose/cellobiose transporter subunit IIA -
  U0447_RS03115 - 603766..604083 (-) 318 WP_001151646.1 PTS sugar transporter subunit IIB -
  U0447_RS03120 - 604098..604994 (-) 897 WP_001865114.1 hypothetical protein -
  U0447_RS03125 - 604997..606259 (-) 1263 WP_000413342.1 PTS sugar transporter subunit IIC -
  U0447_RS03130 - 606539..607717 (+) 1179 WP_000175880.1 ROK family transcriptional regulator -
  U0447_RS03135 - 607945..608391 (-) 447 WP_000155406.1 GNAT family N-acetyltransferase -
  U0447_RS03140 cclA/cilC 608461..609120 (+) 660 WP_000565023.1 A24 family peptidase Machinery gene
  U0447_RS03145 - 609172..610323 (-) 1152 WP_000481750.1 ImmA/IrrE family metallo-endopeptidase -
  U0447_RS03150 - 610338..611069 (-) 732 WP_000934017.1 hypothetical protein -
  U0447_RS03155 - 611295..611399 (+) 105 Protein_622 prepilin peptidase -
  U0447_RS03160 trpA 611371..612147 (-) 777 WP_001127010.1 tryptophan synthase subunit alpha -
  U0447_RS03165 trpB 612140..613363 (-) 1224 WP_000331292.1 tryptophan synthase subunit beta -
  U0447_RS03170 - 613341..613940 (-) 600 WP_000169898.1 phosphoribosylanthranilate isomerase -
  U0447_RS03175 trpC 613927..614694 (-) 768 WP_050232558.1 indole-3-glycerol phosphate synthase TrpC -
  U0447_RS03180 trpD 614691..615695 (-) 1005 WP_000658684.1 anthranilate phosphoribosyltransferase -
  U0447_RS03185 - 615706..616272 (-) 567 WP_000601927.1 aminodeoxychorismate/anthranilate synthase component II -
  U0447_RS03190 trpE 616269..617630 (-) 1362 WP_000439642.1 anthranilate synthase component I -
  U0447_RS03195 - 618002..618163 (-) 162 WP_000693074.1 hypothetical protein -
  U0447_RS03200 - 618771..619772 (-) 1002 WP_000789949.1 LacI family DNA-binding transcriptional regulator -
  U0447_RS03205 - 619880..620247 (-) 368 Protein_632 hypothetical protein -
  U0447_RS03210 - 620343..621053 (-) 711 WP_000127552.1 MgtC/SapB family protein -
  U0447_RS03215 - 621056..622747 (-) 1692 WP_001216185.1 iron ABC transporter permease -
  U0447_RS03220 - 622759..623769 (-) 1011 WP_000589142.1 ABC transporter ATP-binding protein -
  U0447_RS03225 - 623873..624940 (-) 1068 WP_000738372.1 extracellular solute-binding protein -
  U0447_RS03230 - 624965..625624 (-) 660 WP_000793807.1 DUF1868 domain-containing protein -
  U0447_RS03235 - 625804..626118 (-) 315 Protein_638 GDP-mannose 4,6-dehydratase -
  U0447_RS03240 - 626354..626650 (-) 297 WP_000239024.1 hypothetical protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24921.13 Da        Isoelectric Point: 8.2409

>NTDB_id=911391 U0447_RS03140 WP_000565023.1 608461..609120(+) (cclA/cilC) [Streptococcus pneumoniae strain 16H2017-2]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=911391 U0447_RS03140 WP_000565023.1 608461..609120(+) (cclA/cilC) [Streptococcus pneumoniae strain 16H2017-2]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTTCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0I8D2P0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae Rx1

96.347

100

0.963
  cclA/cilC Streptococcus pneumoniae D39

96.347

100

0.963
  cclA/cilC Streptococcus pneumoniae R6

96.347

100

0.963
  cclA/cilC Streptococcus mitis SK321

92.237

100

0.922
  cclA/cilC Streptococcus mitis NCTC 12261

86.301

100

0.863