Detailed information
Bioinformatically predicted
Overview
| Name | ciaH | Type | Regulator |
| Locus tag | SUT_RS04315 | Genome accession | NZ_AP025331 |
| Coordinates | 889444..890814 (+) | Length | 456 a.a. |
| NCBI ID | WP_237373602.1 | Uniprot ID | - |
| Organism | Streptococcus ruminantium strain GUT-183 | ||
| Function | repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 891438..955481 | 889444..890814 | flank | 624 |
Gene organization within MGE regions
Location: 889444..955481
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SUT_RS04315 (GUT183_08080) | ciaH | 889444..890814 (+) | 1371 | WP_237373602.1 | sensor histidine kinase | Regulator |
| SUT_RS04320 (GUT183_08090) | - | 890986..891750 (+) | 765 | WP_227985742.1 | hypothetical protein | - |
| SUT_RS04325 (GUT183_08100) | - | 891750..892937 (+) | 1188 | WP_156019201.1 | DUF1266 domain-containing protein | - |
| SUT_RS04330 (GUT183_08110) | rpsT | 893226..893474 (-) | 249 | WP_075098301.1 | 30S ribosomal protein S20 | - |
| SUT_RS04335 (GUT183_08120) | coaA | 893533..894453 (-) | 921 | WP_155974497.1 | type I pantothenate kinase | - |
| SUT_RS04340 (GUT183_08130) | - | 894566..895156 (+) | 591 | WP_155970964.1 | class I SAM-dependent methyltransferase | - |
| SUT_RS04345 (GUT183_08140) | - | 895153..896430 (+) | 1278 | WP_237373603.1 | pyrimidine-nucleoside phosphorylase | - |
| SUT_RS04350 (GUT183_08150) | deoC | 896446..897108 (+) | 663 | WP_155962911.1 | deoxyribose-phosphate aldolase | - |
| SUT_RS04355 (GUT183_08160) | - | 897095..897484 (+) | 390 | WP_024531705.1 | cytidine deaminase | - |
| SUT_RS04360 (GUT183_08170) | - | 897562..898629 (+) | 1068 | WP_120171602.1 | BMP family lipoprotein | - |
| SUT_RS04365 (GUT183_08180) | - | 898826..900361 (+) | 1536 | WP_155962912.1 | ABC transporter ATP-binding protein | - |
| SUT_RS04370 (GUT183_08190) | - | 900354..901415 (+) | 1062 | WP_024531707.1 | ABC transporter permease | - |
| SUT_RS04375 (GUT183_08200) | - | 901417..902370 (+) | 954 | WP_024531708.1 | ABC transporter permease | - |
| SUT_RS04380 (GUT183_08210) | - | 902602..903585 (-) | 984 | WP_024532867.1 | L-lactate dehydrogenase | - |
| SUT_RS04385 (GUT183_08220) | gyrA | 903773..906217 (+) | 2445 | WP_024532868.1 | DNA gyrase subunit A | - |
| SUT_RS04390 (GUT183_08230) | - | 906224..906970 (+) | 747 | WP_237373604.1 | class A sortase | - |
| SUT_RS04395 (GUT183_08240) | radC | 907161..907841 (+) | 681 | WP_024532870.1 | RadC family protein | - |
| SUT_RS04400 (GUT183_08250) | - | 908243..908881 (-) | 639 | WP_024532871.1 | redox-sensing transcriptional repressor Rex | - |
| SUT_RS04405 (GUT183_08260) | - | 909005..909208 (-) | 204 | WP_024532872.1 | DUF4649 family protein | - |
| SUT_RS04410 (GUT183_08270) | - | 909211..909555 (-) | 345 | WP_024532873.1 | DUF1831 domain-containing protein | - |
| SUT_RS04415 (GUT183_08280) | - | 909558..910673 (-) | 1116 | WP_120171605.1 | cysteine desulfurase family protein | - |
| SUT_RS04420 (GUT183_08290) | - | 910685..911662 (-) | 978 | WP_024532875.1 | ribose-phosphate diphosphokinase | - |
| SUT_RS04425 (GUT183_08300) | - | 911785..912360 (-) | 576 | WP_120171606.1 | CYTH domain-containing protein | - |
| SUT_RS04430 (GUT183_08310) | - | 912600..913271 (+) | 672 | WP_024532877.1 | GTP pyrophosphokinase | - |
| SUT_RS04435 (GUT183_08320) | - | 913255..914073 (+) | 819 | WP_024532878.1 | NAD kinase | - |
| SUT_RS04440 (GUT183_08330) | - | 914073..914966 (+) | 894 | WP_024532879.1 | RluA family pseudouridine synthase | - |
| SUT_RS04445 (GUT183_08340) | pta | 914984..915958 (+) | 975 | WP_024532880.1 | phosphate acetyltransferase | - |
| SUT_RS04450 (GUT183_08350) | - | 915960..917699 (+) | 1740 | WP_237373605.1 | ABC transporter ATP-binding protein | - |
| SUT_RS04455 (GUT183_08360) | - | 917686..919416 (+) | 1731 | WP_237373606.1 | ABC transporter ATP-binding protein | - |
| SUT_RS04460 (GUT183_08370) | - | 919419..919805 (+) | 387 | WP_120172468.1 | PaaI family thioesterase | - |
| SUT_RS04465 (GUT183_08380) | mutY | 920043..921194 (+) | 1152 | WP_165437087.1 | A/G-specific adenine glycosylase | - |
| SUT_RS04470 (GUT183_08390) | - | 921928..922539 (+) | 612 | WP_155962919.1 | hypothetical protein | - |
| SUT_RS04475 (GUT183_08400) | - | 922999..924255 (-) | 1257 | WP_237373607.1 | ISL3 family transposase | - |
| SUT_RS04480 (GUT183_08410) | - | 924411..925952 (-) | 1542 | WP_237373608.1 | ATP-binding cassette domain-containing protein | - |
| SUT_RS04485 (GUT183_08420) | - | 926397..926543 (+) | 147 | WP_237373609.1 | GNAT family N-acetyltransferase | - |
| SUT_RS04490 (GUT183_08440) | - | 926706..928375 (+) | 1670 | Protein_844 | recombinase family protein | - |
| SUT_RS04495 (GUT183_08460) | - | 928441..929058 (+) | 618 | Protein_845 | DNA alkylation repair protein | - |
| SUT_RS04500 (GUT183_08470) | - | 929184..929504 (+) | 321 | WP_237373610.1 | DUF3847 domain-containing protein | - |
| SUT_RS04505 (GUT183_08480) | mobQ | 929744..931228 (+) | 1485 | WP_237373612.1 | MobQ family relaxase | - |
| SUT_RS04510 (GUT183_08490) | - | 931389..932162 (+) | 774 | WP_155996301.1 | helix-turn-helix domain-containing protein | - |
| SUT_RS04515 (GUT183_08500) | - | 932254..932418 (+) | 165 | WP_237373613.1 | transposon-encoded TnpW family protein | - |
| SUT_RS04520 (GUT183_08510) | - | 932526..933266 (-) | 741 | WP_024532886.1 | amino acid ABC transporter ATP-binding protein | - |
| SUT_RS04525 (GUT183_08520) | - | 933266..935464 (-) | 2199 | WP_237373614.1 | ABC transporter substrate-binding protein/permease | - |
| SUT_RS04530 (GUT183_08530) | uvrB | 935660..937645 (+) | 1986 | WP_237373615.1 | excinuclease ABC subunit UvrB | - |
| SUT_RS10285 | - | 937761..938154 (+) | 394 | Protein_853 | N-acetyltransferase family protein | - |
| SUT_RS04540 (GUT183_08560) | - | 938948..939697 (+) | 750 | WP_237373617.1 | ADP-ribosyltransferase | - |
| SUT_RS04545 (GUT183_08580) | - | 940336..941202 (+) | 867 | WP_155974488.1 | MerR family transcriptional regulator | - |
| SUT_RS04550 (GUT183_08590) | eutM | 941685..941963 (+) | 279 | WP_024532891.1 | ethanolamine utilization microcompartment protein EutM | - |
| SUT_RS04555 (GUT183_08600) | - | 942000..942995 (+) | 996 | WP_024532892.1 | DMT family transporter | - |
| SUT_RS04560 (GUT183_08610) | - | 942999..943301 (+) | 303 | WP_024532893.1 | hypothetical protein | - |
| SUT_RS04565 (GUT183_08620) | - | 943298..943594 (+) | 297 | WP_024532894.1 | BMC domain-containing protein | - |
| SUT_RS04570 (GUT183_08630) | - | 943609..943926 (+) | 318 | WP_024532895.1 | BMC domain-containing protein | - |
| SUT_RS04575 (GUT183_08640) | - | 943942..945303 (+) | 1362 | WP_024532896.1 | aldehyde dehydrogenase | - |
| SUT_RS04580 (GUT183_08650) | cutC | 945336..947882 (+) | 2547 | WP_024532897.1 | choline trimethylamine-lyase | - |
| SUT_RS04585 (GUT183_08660) | cutD | 947950..948942 (+) | 993 | WP_024532898.1 | choline TMA-lyase-activating enzyme | - |
| SUT_RS04590 (GUT183_08670) | - | 948964..949311 (+) | 348 | WP_024532899.1 | BMC domain-containing protein | - |
| SUT_RS04595 (GUT183_08680) | - | 949308..949754 (+) | 447 | WP_024532900.1 | EutP/PduV family microcompartment system protein | - |
| SUT_RS04600 (GUT183_08690) | - | 949751..950884 (+) | 1134 | WP_155963813.1 | 1-propanol dehydrogenase PduQ | - |
| SUT_RS04605 (GUT183_08700) | - | 950935..951543 (+) | 609 | WP_024532902.1 | hypothetical protein | - |
| SUT_RS04610 (GUT183_08710) | eutJ | 951521..952363 (+) | 843 | WP_237373618.1 | ethanolamine utilization protein EutJ | - |
| SUT_RS04615 (GUT183_08720) | - | 952373..952672 (+) | 300 | WP_024532904.1 | EutN/CcmL family microcompartment protein | - |
| SUT_RS04620 (GUT183_08730) | - | 952685..953317 (+) | 633 | WP_024532905.1 | cupin domain-containing protein | - |
| SUT_RS10250 (GUT183_08740) | - | 953334..953936 (+) | 603 | WP_155962930.1 | BMC domain-containing protein | - |
Sequence
Protein
Download Length: 456 a.a. Molecular weight: 51995.78 Da Isoelectric Point: 7.2417
>NTDB_id=91138 SUT_RS04315 WP_237373602.1 889444..890814(+) (ciaH) [Streptococcus ruminantium strain GUT-183]
MTKRFRKLVYTDKFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYENSDDTLYRIKEEPAMAVGLAVARAYQPNSELTLQD
NSNRNTTASILDDTMTPQSGNGEQLRLGVNTHVLLYNKNGEIINPDKFTGLSRLTLDKENLDEIRETTVKSSFGLNENYR
YVTIKLVVEELGRYAVYDIKYATILVNVSQIKSSIEKYEATVAVVMVSAWLISILASIYLSNLSMRPILTSYQKQKDFVE
NASHELRTPLAVLQNRLEGLFRHPETTILESSESIGSSLEEVRNMRLLTTNLLNLARRDDGFKLDMVEVPPTYFDEIFDN
YIIIAEENGKKVTVNNLISQSIRTDKVLIKQLLTILFDNAMKYTDDDCDIQITASIKDKLVCFTIADNGLGITDNDKKKI
FDRFYRVDKARTRQKGGFGLGLSLAQQIIKALNGEIFVRDNQPKGTVFEVQLPIKK
MTKRFRKLVYTDKFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYENSDDTLYRIKEEPAMAVGLAVARAYQPNSELTLQD
NSNRNTTASILDDTMTPQSGNGEQLRLGVNTHVLLYNKNGEIINPDKFTGLSRLTLDKENLDEIRETTVKSSFGLNENYR
YVTIKLVVEELGRYAVYDIKYATILVNVSQIKSSIEKYEATVAVVMVSAWLISILASIYLSNLSMRPILTSYQKQKDFVE
NASHELRTPLAVLQNRLEGLFRHPETTILESSESIGSSLEEVRNMRLLTTNLLNLARRDDGFKLDMVEVPPTYFDEIFDN
YIIIAEENGKKVTVNNLISQSIRTDKVLIKQLLTILFDNAMKYTDDDCDIQITASIKDKLVCFTIADNGLGITDNDKKKI
FDRFYRVDKARTRQKGGFGLGLSLAQQIIKALNGEIFVRDNQPKGTVFEVQLPIKK
Nucleotide
Download Length: 1371 bp
>NTDB_id=91138 SUT_RS04315 WP_237373602.1 889444..890814(+) (ciaH) [Streptococcus ruminantium strain GUT-183]
ATGACTAAGCGATTTAGAAAGCTAGTTTACACGGATAAATTTTCTTTCTTTATCCGCTATTTTGCAGTCTTTACTCTGAT
TTTTGGTCTGATGACAGCTATCATCTTTCAATTGATGCGTTCAACCATGTATGAAAATTCGGATGACACGCTATATCGAA
TCAAAGAAGAACCTGCAATGGCAGTTGGACTGGCAGTGGCGAGAGCCTATCAACCGAATTCAGAACTCACTCTCCAAGAC
AATTCAAATAGGAATACGACGGCTTCCATTTTGGATGATACGATGACGCCCCAAAGCGGAAATGGGGAACAATTGAGGTT
GGGAGTGAATACTCACGTACTGCTGTATAACAAGAATGGTGAAATCATTAACCCTGATAAATTCACCGGCTTATCAAGGT
TGACCTTAGACAAGGAAAATTTAGATGAAATTAGGGAAACGACCGTTAAATCTTCTTTTGGTTTGAATGAAAATTATCGT
TATGTAACGATTAAACTGGTAGTCGAGGAACTCGGTCGTTATGCGGTTTACGATATAAAGTATGCAACTATCCTAGTGAA
TGTTAGCCAAATTAAATCATCTATTGAGAAGTATGAAGCAACAGTTGCTGTTGTAATGGTTTCTGCTTGGTTGATTTCTA
TCTTGGCAAGTATTTACTTGTCCAATCTTAGTATGCGTCCTATTTTGACTAGCTATCAGAAACAAAAGGATTTTGTGGAA
AATGCCAGTCATGAGCTACGTACACCATTAGCTGTTTTACAGAACCGCTTGGAAGGGTTGTTCCGTCATCCTGAAACGAC
CATTTTGGAAAGTAGCGAAAGTATCGGATCTAGTTTGGAGGAGGTCCGCAATATGCGGTTACTGACGACCAATTTGCTCA
ATCTCGCACGCCGGGATGATGGTTTTAAACTAGATATGGTAGAAGTACCTCCTACCTATTTTGATGAAATATTTGATAAC
TATATTATAATTGCTGAAGAAAACGGCAAGAAGGTGACTGTCAACAATTTAATTAGCCAGTCTATTCGAACGGACAAAGT
TTTAATTAAGCAATTGCTGACTATCTTATTTGATAATGCAATGAAATACACCGATGATGATTGCGATATTCAAATTACAG
CCAGTATAAAAGATAAATTAGTCTGCTTTACCATTGCGGATAATGGCTTAGGAATTACCGACAACGACAAAAAGAAAATA
TTTGATCGTTTCTATCGGGTTGATAAGGCTAGAACACGTCAAAAGGGTGGATTCGGTCTAGGCTTATCTTTGGCGCAGCA
GATTATCAAGGCTCTGAATGGAGAAATTTTCGTTAGGGATAATCAGCCTAAAGGGACTGTTTTTGAGGTGCAACTTCCAA
TCAAAAAATAA
ATGACTAAGCGATTTAGAAAGCTAGTTTACACGGATAAATTTTCTTTCTTTATCCGCTATTTTGCAGTCTTTACTCTGAT
TTTTGGTCTGATGACAGCTATCATCTTTCAATTGATGCGTTCAACCATGTATGAAAATTCGGATGACACGCTATATCGAA
TCAAAGAAGAACCTGCAATGGCAGTTGGACTGGCAGTGGCGAGAGCCTATCAACCGAATTCAGAACTCACTCTCCAAGAC
AATTCAAATAGGAATACGACGGCTTCCATTTTGGATGATACGATGACGCCCCAAAGCGGAAATGGGGAACAATTGAGGTT
GGGAGTGAATACTCACGTACTGCTGTATAACAAGAATGGTGAAATCATTAACCCTGATAAATTCACCGGCTTATCAAGGT
TGACCTTAGACAAGGAAAATTTAGATGAAATTAGGGAAACGACCGTTAAATCTTCTTTTGGTTTGAATGAAAATTATCGT
TATGTAACGATTAAACTGGTAGTCGAGGAACTCGGTCGTTATGCGGTTTACGATATAAAGTATGCAACTATCCTAGTGAA
TGTTAGCCAAATTAAATCATCTATTGAGAAGTATGAAGCAACAGTTGCTGTTGTAATGGTTTCTGCTTGGTTGATTTCTA
TCTTGGCAAGTATTTACTTGTCCAATCTTAGTATGCGTCCTATTTTGACTAGCTATCAGAAACAAAAGGATTTTGTGGAA
AATGCCAGTCATGAGCTACGTACACCATTAGCTGTTTTACAGAACCGCTTGGAAGGGTTGTTCCGTCATCCTGAAACGAC
CATTTTGGAAAGTAGCGAAAGTATCGGATCTAGTTTGGAGGAGGTCCGCAATATGCGGTTACTGACGACCAATTTGCTCA
ATCTCGCACGCCGGGATGATGGTTTTAAACTAGATATGGTAGAAGTACCTCCTACCTATTTTGATGAAATATTTGATAAC
TATATTATAATTGCTGAAGAAAACGGCAAGAAGGTGACTGTCAACAATTTAATTAGCCAGTCTATTCGAACGGACAAAGT
TTTAATTAAGCAATTGCTGACTATCTTATTTGATAATGCAATGAAATACACCGATGATGATTGCGATATTCAAATTACAG
CCAGTATAAAAGATAAATTAGTCTGCTTTACCATTGCGGATAATGGCTTAGGAATTACCGACAACGACAAAAAGAAAATA
TTTGATCGTTTCTATCGGGTTGATAAGGCTAGAACACGTCAAAAGGGTGGATTCGGTCTAGGCTTATCTTTGGCGCAGCA
GATTATCAAGGCTCTGAATGGAGAAATTTTCGTTAGGGATAATCAGCCTAAAGGGACTGTTTTTGAGGTGCAACTTCCAA
TCAAAAAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ciaH | Streptococcus pneumoniae Rx1 |
49.561 |
100 |
0.496 |
| ciaH | Streptococcus pneumoniae D39 |
49.561 |
100 |
0.496 |
| ciaH | Streptococcus pneumoniae R6 |
49.561 |
100 |
0.496 |
| ciaH | Streptococcus pneumoniae TIGR4 |
49.561 |
100 |
0.496 |
| ciaH | Streptococcus mutans UA159 |
48.565 |
99.342 |
0.482 |