Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   ABC811_RS04280 Genome accession   NZ_CP155535
Coordinates   832183..833532 (+) Length   449 a.a.
NCBI ID   WP_000886210.1    Uniprot ID   Q8DPL8
Organism   Streptococcus pneumoniae strain PJ755/1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 827183..838532
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC811_RS04255 (ABC811_04255) coaB 827339..828028 (-) 690 WP_000699494.1 phosphopantothenate--cysteine ligase -
  ABC811_RS04260 (ABC811_04260) - 828258..829928 (+) 1671 WP_000845273.1 formate--tetrahydrofolate ligase -
  ABC811_RS04265 (ABC811_04265) - 830034..830159 (-) 126 WP_001818232.1 hypothetical protein -
  ABC811_RS04270 (ABC811_04270) mutY 830256..831431 (+) 1176 WP_000886148.1 A/G-specific adenine glycosylase -
  ABC811_RS04275 (ABC811_04275) yycF 831486..832190 (+) 705 WP_050144106.1 response regulator YycF -
  ABC811_RS04280 (ABC811_04280) micB 832183..833532 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ABC811_RS04285 (ABC811_04285) vicX 833534..834343 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  ABC811_RS04290 (ABC811_04290) relB 834434..834676 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  ABC811_RS04295 (ABC811_04295) - 834678..834932 (+) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ABC811_RS04300 (ABC811_04300) - 834979..835752 (+) 774 WP_000731131.1 ion transporter -
  ABC811_RS04305 (ABC811_04305) - 836012..836998 (-) 987 WP_000204724.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51712.42 Da        Isoelectric Point: 4.9706

>NTDB_id=897031 ABC811_RS04280 WP_000886210.1 832183..833532(+) (micB) [Streptococcus pneumoniae strain PJ755/1]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=897031 ABC811_RS04280 WP_000886210.1 832183..833532(+) (micB) [Streptococcus pneumoniae strain PJ755/1]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterProScan.

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DPL8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.777

100

0.998
  vicK Streptococcus mutans UA159

69.9

89.532

0.626