Detailed information NTG0896284

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R4705_RS07815
• Genome accession: NZ_CP137115
• Coordinates: 1486360..1487097 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219127.1
• Uniprot ID: A0A4J1ZS24
• Organism: Streptococcus pneumoniae strain 20614-6
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1481360..1492097

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4705_RS07780	-	1482336..1482530 (-)	195	WP_001808905.1	hypothetical protein	-
R4705_RS07785	-	1482692..1482979 (-)	288	WP_000777760.1	hypothetical protein	-
R4705_RS07790	-	1482989..1483399 (-)	411	WP_001278301.1	HIT family protein	-
R4705_RS07795	pptA	1483467..1484198 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
R4705_RS07800	-	1484195..1485244 (+)	1050	WP_000653752.1	ABC transporter permease	-
R4705_RS07805	-	1485412..1485741 (-)	330	WP_000132570.1	hypothetical protein	-
R4705_RS07810	-	1486017..1486355 (+)	339	WP_000682119.1	LytTR family DNA-binding domain-containing protein	-
R4705_RS07815	comE/blpR	1486360..1487097 (+)	738	WP_001219127.1	response regulator transcription factor	Regulator
R4705_RS07820	-	1487111..1488451 (+)	1341	WP_001017622.1	sensor histidine kinase	-
R4705_RS07825	blpC	1488493..1488648 (-)	156	WP_000358813.1	quorum-sensing system pheromone BlpC	-
R4705_RS07830	-	1488705..1490066 (-)	1362	WP_001069092.1	bacteriocin secretion accessory protein	-
R4705_RS07835	comA/nlmT	1490077..1490565 (-)	489	WP_307774349.1	ATP-binding cassette domain-containing protein	Regulator
R4705_RS07840	comA/nlmT	1490549..1490989 (-)	441	WP_001808911.1	ATP-binding cassette domain-containing protein	Regulator
R4705_RS07845	comA/nlmT	1490979..1491704 (-)	726	WP_167750760.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28683.81 Da
• Isoelectric Point: 6.0431

>NTDB_id=896284 R4705_RS07815 WP_001219127.1 1486360..1487097(+) (comE/blpR) [Streptococcus pneumoniae strain 20614-6]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPSLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=896284 R4705_RS07815 WP_001219127.1 1486360..1487097(+) (comE/blpR) [Streptococcus pneumoniae strain 20614-6]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTACATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTAGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCAGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A4J1ZS24

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.498	99.184	0.531
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384