Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R4700_RS08030 Genome accession   NZ_CP137112
Coordinates   1561590..1562327 (+) Length   245 a.a.
NCBI ID   WP_001219126.1    Uniprot ID   A7XHJ0
Organism   Streptococcus pneumoniae strain 02H2025     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1556590..1567327
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4700_RS07995 - 1557564..1557740 (-) 177 WP_277770848.1 hypothetical protein -
  R4700_RS08000 - 1557922..1558209 (-) 288 WP_000777760.1 hypothetical protein -
  R4700_RS08005 - 1558219..1558629 (-) 411 WP_001278301.1 HIT family protein -
  R4700_RS08010 pptA 1558697..1559428 (+) 732 WP_001866897.1 ABC transporter ATP-binding protein Regulator
  R4700_RS08015 - 1559425..1560474 (+) 1050 WP_288160555.1 ABC transporter permease -
  R4700_RS08020 - 1560642..1560971 (-) 330 WP_088795779.1 helicase BlpT -
  R4700_RS08025 - 1561247..1561585 (+) 339 WP_000682121.1 LytTR family DNA-binding domain-containing protein -
  R4700_RS08030 comE/blpR 1561590..1562327 (+) 738 WP_001219126.1 response regulator transcription factor Regulator
  R4700_RS08035 - 1562341..1563681 (+) 1341 WP_277770850.1 sensor histidine kinase -
  R4700_RS08040 blpC 1563752..1563880 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  R4700_RS08045 - 1563937..1565298 (-) 1362 WP_277770851.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28752.92 Da        Isoelectric Point: 6.2357

>NTDB_id=896053 R4700_RS08030 WP_001219126.1 1561590..1562327(+) (comE/blpR) [Streptococcus pneumoniae strain 02H2025]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=896053 R4700_RS08030 WP_001219126.1 1561590..1562327(+) (comE/blpR) [Streptococcus pneumoniae strain 02H2025]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTAGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A7XHJ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384