Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   R4706_RS07685 Genome accession   NZ_CP137111
Coordinates   1495524..1496183 (-) Length   219 a.a.
NCBI ID   WP_000565023.1    Uniprot ID   A0A0I8D2P0
Organism   Streptococcus pneumoniae strain 17023     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1496927..1512303 1495524..1496183 flank 744


Gene organization within MGE regions


Location: 1495524..1512303
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4706_RS07685 cclA/cilC 1495524..1496183 (-) 660 WP_000565023.1 A24 family peptidase Machinery gene
  R4706_RS07690 - 1496253..1496699 (+) 447 WP_000155406.1 GNAT family N-acetyltransferase -
  R4706_RS07695 - 1496927..1498105 (-) 1179 WP_000175876.1 ROK family transcriptional regulator -
  R4706_RS07700 - 1498385..1499647 (+) 1263 WP_000413336.1 PTS sugar transporter subunit IIC -
  R4706_RS07705 - 1499650..1500546 (+) 897 WP_000825669.1 PEP phosphonomutase -
  R4706_RS07710 - 1500561..1500878 (+) 318 WP_001151646.1 PTS sugar transporter subunit IIB -
  R4706_RS07715 - 1500895..1501212 (+) 318 WP_001005881.1 PTS lactose/cellobiose transporter subunit IIA -
  R4706_RS07720 - 1501222..1502577 (+) 1356 WP_057516331.1 PTS sugar transporter subunit IIC -
  R4706_RS07725 - 1502900..1504375 (+) 1476 WP_000250870.1 arylsulfatase -
  R4706_RS07730 - 1504372..1505220 (+) 849 WP_000782429.1 formylglycine-generating enzyme family protein -
  R4706_RS07735 - 1505235..1506005 (+) 771 WP_000229332.1 sulfite exporter TauE/SafE family protein -
  R4706_RS07740 - 1506283..1506528 (-) 246 WP_057516330.1 hypothetical protein -
  R4706_RS07745 - 1506800..1507045 (+) 246 WP_255296894.1 transposase -
  R4706_RS07750 - 1507155..1507358 (-) 204 WP_000109957.1 CsbD family protein -
  R4706_RS07755 - 1507389..1507997 (-) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  R4706_RS07760 - 1508036..1508206 (-) 171 WP_000455066.1 DUF2273 domain-containing protein -
  R4706_RS07765 amaP 1508218..1508784 (-) 567 WP_000030209.1 alkaline shock response membrane anchor protein AmaP -
  R4706_RS07770 - 1508868..1509090 (-) 223 Protein_1485 GlsB/YeaQ/YmgE family stress response membrane protein -
  R4706_RS07775 mgaSpn 1509474..1510946 (+) 1473 WP_138026158.1 virulence factor transcriptional regulator MgaSpn -
  R4706_RS07780 - 1511308..1512303 (+) 996 WP_000230210.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24921.13 Da        Isoelectric Point: 8.2409

>NTDB_id=895978 R4706_RS07685 WP_000565023.1 1495524..1496183(-) (cclA/cilC) [Streptococcus pneumoniae strain 17023]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=895978 R4706_RS07685 WP_000565023.1 1495524..1496183(-) (cclA/cilC) [Streptococcus pneumoniae strain 17023]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0I8D2P0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae Rx1

96.347

100

0.963
  cclA/cilC Streptococcus pneumoniae D39

96.347

100

0.963
  cclA/cilC Streptococcus pneumoniae R6

96.347

100

0.963
  cclA/cilC Streptococcus mitis SK321

92.237

100

0.922
  cclA/cilC Streptococcus mitis NCTC 12261

86.301

100

0.863