Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   R4706_RS06910 Genome accession   NZ_CP137111
Coordinates   1366497..1367117 (+) Length   206 a.a.
NCBI ID   WP_000839909.1    Uniprot ID   A0A098Z2X2
Organism   Streptococcus pneumoniae strain 17023     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1357192..1376421 1366497..1367117 within 0


Gene organization within MGE regions


Location: 1357192..1376421
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4706_RS06865 - 1357192..1359300 (-) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  R4706_RS06870 - 1359297..1360226 (-) 930 WP_000912954.1 M50 family metallopeptidase -
  R4706_RS06875 - 1360207..1360911 (-) 705 WP_001033170.1 flavodoxin family protein -
  R4706_RS06880 - 1361261..1362271 (-) 1011 WP_001812207.1 lanthionine synthetase LanC family protein -
  R4706_RS06885 lanM 1362313..1364250 (-) 1938 WP_001837267.1 type 2 lanthipeptide synthetase LanM -
  R4706_RS06890 pneA2 1364367..1364555 (-) 189 WP_050198750.1 two-peptide bacteriocin subunit PneA2 -
  R4706_RS06895 pneA1 1364562..1364786 (-) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  R4706_RS06900 - 1364889..1365059 (-) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  R4706_RS06905 - 1365251..1366114 (+) 864 WP_001093620.1 helix-turn-helix domain-containing protein -
  R4706_RS06910 comM 1366497..1367117 (+) 621 WP_000839909.1 hypothetical protein Regulator
  R4706_RS06915 tsaE 1367203..1367646 (+) 444 WP_000288230.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  R4706_RS06920 - 1367636..1368154 (+) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  R4706_RS06925 brpA 1368162..1369178 (+) 1017 WP_000239278.1 biofilm formation/cell division transcriptional regulator BrpA -
  R4706_RS06930 cinA 1369263..1370519 (+) 1257 WP_000642707.1 competence/damage-inducible protein A Machinery gene
  R4706_RS06935 recA 1370574..1371740 (+) 1167 WP_001085463.1 recombinase RecA Machinery gene
  R4706_RS06940 - 1372047..1373417 (+) 1371 WP_001036282.1 MATE family efflux transporter -
  R4706_RS06945 lytA 1373793..1374749 (+) 957 WP_000405236.1 N-acetylmuramoyl-L-alanine amidase LytA -
  R4706_RS06950 - 1375108..1375269 (+) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  R4706_RS06955 - 1375256..1375867 (+) 612 WP_224757307.1 ImmA/IrrE family metallo-endopeptidase -
  R4706_RS06960 - 1375996..1376421 (+) 426 WP_000204067.1 hypothetical protein -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23540.66 Da        Isoelectric Point: 10.1254

>NTDB_id=895966 R4706_RS06910 WP_000839909.1 1366497..1367117(+) (comM) [Streptococcus pneumoniae strain 17023]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=895966 R4706_RS06910 WP_000839909.1 1366497..1367117(+) (comM) [Streptococcus pneumoniae strain 17023]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A098Z2X2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

99.515

100

0.995
  comM Streptococcus pneumoniae R6

99.515

100

0.995
  comM Streptococcus pneumoniae TIGR4

99.515

100

0.995
  comM Streptococcus mitis NCTC 12261

38.462

94.66

0.364
  comM Streptococcus mitis SK321

38.462

94.66

0.364